MIR1199

Summary

MIR1199 (microRNA 1199, HGNC:50081) is a microRNA gene on chromosome 19p13.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466515 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50081
Approved symbol	MIR1199
Name	microRNA 1199
Location	19p13.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1199
Ensembl gene	ENSG00000284081
Ensembl biotype	miRNA
Entrez	102466515
RNAcentral	URS000075B871 — miRNA, 119 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000621445

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000621445 — 1 exons

Exon	Start	End
ENSE00003751120	14073361	14073479

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 71.07.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	71.07	gold quality
lung	UBERON:0002048	68.77	gold quality
cerebral cortex	UBERON:0000956	66.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.77	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.22	gold quality
omental fat pad	UBERON:0010414	61.54	gold quality
liver	UBERON:0002107	61.05	gold quality
prostate gland	UBERON:0002367	60.01	gold quality
esophagus mucosa	UBERON:0002469	58.61	gold quality
left ovary	UBERON:0002119	57.35	gold quality
gastrocnemius	UBERON:0001388	55.42	gold quality
ascending aorta	UBERON:0001496	51.03	gold quality
left uterine tube	UBERON:0001303	43.93	gold quality
left testis	UBERON:0004533	36.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Upregulation of mir-1199-5p is associated with reduced type 2 5-alpha reductase expression in benign prostatic hyperplasia. (PMID:36344974)
• MicroR-1199-5p targeting SRD5A2 promotes the biological behavior and EMT of hypospadias cells. (PMID:38836672)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.