MIR1200

Summary

MIR1200 (microRNA 1200, HGNC:35266) is a microRNA gene on chromosome 7p14.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302113 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35266
Approved symbol	MIR1200
Name	microRNA 1200
Location	7p14.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1200
Ensembl gene	ENSG00000221325
Ensembl biotype	miRNA
Entrez	100302113
RNAcentral	URS000075A6E3 — miRNA, 76 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408398

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408398 — 1 exons

Exon	Start	End
ENSE00001565033	36919357	36919432

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 97.64.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.64	gold quality
corpus callosum	UBERON:0002336	94.98	gold quality
blood	UBERON:0000178	85.14	gold quality
adrenal tissue	UBERON:0018303	84.61	gold quality
calcaneal tendon	UBERON:0003701	83.23	gold quality
kidney	UBERON:0002113	81.60	gold quality
adult mammalian kidney	UBERON:0000082	79.84	gold quality
liver	UBERON:0002107	79.49	gold quality
bone marrow	UBERON:0002371	78.78	gold quality
stomach	UBERON:0000945	77.82	gold quality
monocyte	CL:0000576	77.16	gold quality
gastrocnemius	UBERON:0001388	72.19	gold quality
islet of Langerhans	UBERON:0000006	72.16	gold quality
heart left ventricle	UBERON:0002084	71.24	gold quality
heart	UBERON:0000948	70.51	gold quality
right adrenal gland	UBERON:0001233	70.30	gold quality
lung	UBERON:0002048	69.08	gold quality
right atrium auricular region	UBERON:0006631	68.62	gold quality
ectocervix	UBERON:0012249	68.47	gold quality
intestine	UBERON:0000160	68.12	gold quality
multicellular organism	UBERON:0000468	67.19	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.12	gold quality
body of stomach	UBERON:0001161	67.03	gold quality
amygdala	UBERON:0001876	66.30	gold quality
lower esophagus	UBERON:0013473	66.29	gold quality
tibial artery	UBERON:0007610	66.23	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.18	gold quality
fundus of stomach	UBERON:0001160	65.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.91	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.90	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.79

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• circ-0001785 regulates the pathogenesis of osteosarcoma by sponging miR-1200 to up-regulate HOXB2 expression. (PMID:31116090)
• Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway. (PMID:32855967)
• Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis. (PMID:34516311)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.