MIR1202

Summary

MIR1202 (microRNA 1202, HGNC:35268) is a microRNA gene on chromosome 6q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302259 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35268
Approved symbol	MIR1202
Name	microRNA 1202
Location	6q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1202
Ensembl gene	ENSG00000221456
Ensembl biotype	miRNA
Entrez	100302259
RNAcentral	URS000075E4E5 — miRNA, 83 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408529

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408529 — 1 exons

Exon	Start	End
ENSE00001565164	155946797	155946879

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 80.90.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.90	gold quality
monocyte	CL:0000576	73.34	gold quality
calcaneal tendon	UBERON:0003701	71.93	gold quality
heart	UBERON:0000948	71.53	gold quality
gastrocnemius	UBERON:0001388	70.22	gold quality
Ammon’s horn	UBERON:0001954	67.16	gold quality
tibial artery	UBERON:0007610	66.63	gold quality
body of uterus	UBERON:0009853	64.84	gold quality
amygdala	UBERON:0001876	64.75	gold quality
ascending aorta	UBERON:0001496	64.66	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.25	gold quality
esophagus mucosa	UBERON:0002469	64.02	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.87	gold quality
omental fat pad	UBERON:0010414	63.64	gold quality
body of stomach	UBERON:0001161	62.95	gold quality
skin of leg	UBERON:0001511	62.54	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.24	gold quality
minor salivary gland	UBERON:0001830	61.53	gold quality
skin of abdomen	UBERON:0001416	60.98	gold quality
vagina	UBERON:0000996	59.58	gold quality
thyroid gland	UBERON:0002046	59.25	gold quality
right lobe of thyroid gland	UBERON:0001119	59.02	gold quality
left lobe of thyroid gland	UBERON:0001120	58.96	gold quality
tibial nerve	UBERON:0001323	58.56	gold quality
upper lobe of left lung	UBERON:0008952	57.56	gold quality
spleen	UBERON:0002106	57.14	gold quality
pituitary gland	UBERON:0000007	56.69	gold quality
thoracic mammary gland	UBERON:0005200	56.16	gold quality
corpus callosum	UBERON:0002336	53.96	gold quality
colon	UBERON:0001155	47.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• results suggest that miR-1202 is associated with the pathophysiology of depression and is a potential target for new antidepressant treatments (PMID:24908571)
• Evidence show that miR-1202 exists in a dose-dependent relationship with expression of the gene GRM4 in the human prefrontal cortex and its expression is related to successful antidepressant treatment. (PMID:25315250)
• We found that either miR-1202 silencing or miR-196a overexpression affected AN3CA and HEC-1-A cells by increasing their apoptosis level and inducing G1 phase arrest while decreasing their migratory and invasive abilities. Inhibitors of miR-1202 and miR196a may exert a protective effect, suggesting that miR-1202 and miR196a may serve as biomarkers for evaluating the effectiveness of endometrial cancer treatment (PMID:28440476)
• our data indicate that miR-1202 suppresses proliferation and induces endoplasmic reticulum stress and apoptosis through targeting and inhibiting Rab1A in glioma cells. These results suggest miR-1202 as a potential therapeutic target for the treatment of glioma patients. (PMID:28443461)
• CDK14 mediated miR-1202 to exert its anti-tumor effects. (PMID:29217161)
• Changes in expression of lncRNA-GAS5, miRNA-661, miRNA-1202 and MMP9 in M2 macrophages are involved in varicose disease. (PMID:30558403)
• MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-kappaB Signaling Pathway. (PMID:32124161)
• MicroRNA-1202 plays a vital role in osteoarthritis via KCNQ1OT1 has-miR-1202-ETS1 regulatory pathway. (PMID:32252801)
• MiRNA-1202 promotes the TGF-beta1-induced proliferation, differentiation and collagen production of cardiac fibroblasts by targeting nNOS. (PMID:34428251)
• IGF2BP3 Worsens Lung Cancer through Modifying Long Non-coding RNA CERS6-AS1/microRNA-1202 Axis. (PMID:35702784)
• Involvement of FAM170B-AS1, hsa-miR-1202, and hsa-miR-146a-5p in breast cancer. (PMID:38250762)
• miR-1202 acts as anti-oncomiR in myeloid leukaemia by down-modulating GATA-1S expression. (PMID:38350611)
• miR-1202 regulates BPH-1 cell proliferation, apoptosis, and epithelial-to-mesenchymal transition through targeting HMGCL. (PMID:38551020)
• Exosomal miR-1202 mediates Brodmann Area 44 functional connectivity changes in medication-free patients with major depressive disorder: An fMRI study. (PMID:38608766)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.