MIR1203

Summary

MIR1203 (microRNA 1203, HGNC:35269) is a microRNA gene on chromosome 17q21.32.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302211 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35269
Approved symbol	MIR1203
Name	microRNA 1203
Location	17q21.32
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1203
Ensembl gene	ENSG00000221739
Ensembl biotype	miRNA
Entrez	100302211
RNAcentral	URS000075D682 — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408812

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408812 — 1 exons

Exon	Start	End
ENSE00001565447	48156427	48156511

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 80.18.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.18	gold quality
heart left ventricle	UBERON:0002084	76.70	gold quality
monocyte	CL:0000576	76.55	gold quality
liver	UBERON:0002107	74.62	gold quality
gastrocnemius	UBERON:0001388	74.08	gold quality
heart	UBERON:0000948	73.12	gold quality
adrenal tissue	UBERON:0018303	73.10	gold quality
right atrium auricular region	UBERON:0006631	72.31	gold quality
ascending aorta	UBERON:0001496	71.44	gold quality
right lobe of liver	UBERON:0001114	71.28	gold quality
body of pancreas	UBERON:0001150	70.92	gold quality
metanephros cortex	UBERON:0010533	70.77	gold quality
Ammon’s horn	UBERON:0001954	70.51	gold quality
tibial artery	UBERON:0007610	69.72	gold quality
body of stomach	UBERON:0001161	69.44	gold quality
endometrium	UBERON:0001295	69.32	gold quality
corpus callosum	UBERON:0002336	69.20	gold quality
multicellular organism	UBERON:0000468	69.03	gold quality
stomach	UBERON:0000945	68.74	gold quality
granulocyte	CL:0000094	68.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.36	gold quality
right adrenal gland cortex	UBERON:0035827	67.17	gold quality
adrenal gland	UBERON:0002369	66.95	gold quality
left adrenal gland	UBERON:0001234	66.93	gold quality
right adrenal gland	UBERON:0001233	66.47	gold quality
esophagus mucosa	UBERON:0002469	65.78	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.01	gold quality
skin of abdomen	UBERON:0001416	65.00	gold quality
amygdala	UBERON:0001876	64.90	gold quality
left adrenal gland cortex	UBERON:0035825	64.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• MiR-1203 is involved in hepatocellular carcinoma metastases and indicates a poor prognosis. (PMID:31847527)
• microRNA-1203 targets and silences cyclophilin D to protect human endometrial cells from oxygen and glucose deprivation-re-oxygenation. (PMID:32041924)
• LINC00632 inhibits the malignant development of non-small cell lung cancer by downregulating miR-1203. (PMID:32862599)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.