MIR1204

Summary

MIR1204 (microRNA 1204, HGNC:37059) is a microRNA gene on chromosome 8q24.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302185 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37059
Approved symbol	MIR1204
Name	microRNA 1204
Location	8q24.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1204
Ensembl gene	ENSG00000283710
Ensembl biotype	miRNA
Entrez	100302185
RNAcentral	URS000075D2B1 — miRNA, 67 nt, 19 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408388

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408388 — 1 exons

Exon	Start	End
ENSE00001565023	127795962	127796028

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 67.24.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagogastric junction muscularis propria	UBERON:0035841	67.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.77	gold quality
esophagus mucosa	UBERON:0002469	62.33	gold quality
blood	UBERON:0000178	61.87	gold quality
skin of leg	UBERON:0001511	59.67	gold quality
omental fat pad	UBERON:0010414	54.29	gold quality
gastrocnemius	UBERON:0001388	52.26	gold quality
tibial nerve	UBERON:0001323	50.70	gold quality
right testis	UBERON:0004534	41.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• p53-Dependent induction of PVT1 and miR-1204. (PMID:22110125)
• MiR-1204 sensitizes nasopharyngeal carcinoma cells to paclitaxel both in vitro and in vivo (PMID:25756509)
• High miR1204 expression is associated with epithelial-mesenchymal transition and metastasis in breast cancer. (PMID:29555976)
• MiR-1204 promotes ovarian squamous cell carcinoma growth by increasing glucose uptake. (PMID:30304996)
• upregulated miR-1204 in non-small-cell lung cancer (NSCLC) is associated with NSCLC progression and promotes NSCLC cell proliferation by downregulating PITX1. (PMID:30549141)
• MiR-1204 induces apoptosis of non-small cell lung cancer cells by inhibiting the expression of DEK. The mechanism of apoptosis involves down-regulation of Bcl-2 and up-regulation of Bax expression. (PMID:31246264)
• miR-1204 Positioning in 8q24.21 Involved in the Tumorigenesis of Colorectal Cancer by Targeting MASPIN. (PMID:39082173)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.