MIR1205

Summary

MIR1205 (microRNA 1205, HGNC:35271) is a microRNA gene on chromosome 8q24.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302161 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35271
Approved symbol	MIR1205
Name	microRNA 1205
Location	8q24.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1205
Ensembl gene	ENSG00000221771
Ensembl biotype	miRNA
Entrez	100302161
RNAcentral	URS000075B1EF — miRNA, 63 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408844

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408844 — 1 exons

Exon	Start	End
ENSE00001565479	127960633	127960695

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 85.37.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	85.37	gold quality
bone marrow	UBERON:0002371	78.43	gold quality
blood	UBERON:0000178	78.26	gold quality
kidney	UBERON:0002113	77.98	gold quality
granulocyte	CL:0000094	76.70	gold quality
monocyte	CL:0000576	75.97	gold quality
calcaneal tendon	UBERON:0003701	75.32	gold quality
gastrocnemius	UBERON:0001388	74.40	gold quality
caudate nucleus	UBERON:0001873	73.89	gold quality
heart	UBERON:0000948	73.15	gold quality
lymph node	UBERON:0000029	73.09	gold quality
adrenal gland	UBERON:0002369	73.02	gold quality
heart left ventricle	UBERON:0002084	72.64	gold quality
right lobe of liver	UBERON:0001114	72.07	gold quality
endometrium	UBERON:0001295	71.95	gold quality
liver	UBERON:0002107	71.71	gold quality
body of pancreas	UBERON:0001150	70.95	gold quality
smooth muscle tissue	UBERON:0001135	70.72	gold quality
right atrium auricular region	UBERON:0006631	70.60	gold quality
tibial artery	UBERON:0007610	70.26	gold quality
stomach	UBERON:0000945	69.96	gold quality
lung	UBERON:0002048	69.11	gold quality
ascending aorta	UBERON:0001496	68.95	gold quality
anterior cingulate cortex	UBERON:0009835	68.27	gold quality
right adrenal gland	UBERON:0001233	68.20	gold quality
body of stomach	UBERON:0001161	68.13	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.99	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.96	gold quality
left adrenal gland	UBERON:0001234	67.88	gold quality
omental fat pad	UBERON:0010414	67.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 14)

• Circular RNA circ_0034642/miR-1205/BATF3 pathway may play an important role in glioma. (PMID:30551880)
• miR-1205 was down-regulated in the tissues of lung adenocarcinoma, and that miR-1205 may be a predictor of overall survival of lung adenocarcinoma. (PMID:30779081)
• By targeting EGLN3, miR-1205 has an oncogenic role and may contribute to the genetic risk of castration-resistant prostate cancer. (PMID:30808975)
• Upregulation of circular RNA circ_0034642 indicates unfavorable prognosis in glioma and facilitates cell proliferation and invasion via the miR-1205/BATF3 axis. (PMID:30938850)
• Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR-1179/ABCA9 and miR-1205/MTA1 signaling pathways. (PMID:31270819)
• Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma. (PMID:31801947)
• Circ_0082182 promotes oncogenesis and metastasis of colorectal cancer in vitro and in vivo by sponging miR-411 and miR-1205 to activate the Wnt/beta-catenin pathway. (PMID:33596920)
• Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis. (PMID:33634427)
• CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205. (PMID:34127015)
• CircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis. (PMID:34180753)
• CircFAM120B knockdown inhibits osteosarcoma tumorigenesis via the miR-1205/PTBP1 axis. (PMID:34716285)
• MicroRNA-1205 Suppresses Hepatocellular Carcinoma Cell Proliferation via a CSNK2B/CDK4 Axis. (PMID:36617978)
• Downregulation of circular RNA ETS1 promotes SLE activity and inhibits Treg cell differentiation through miR-1205/FoxP3 molecular axis. (PMID:38244519)
• MicroRNA-1205 promotes breast cancer cell metastasis by regulating epithelial-to-mesenchymal transition via targeting of CDK3. (PMID:38897528)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.