MIR1206

Summary

MIR1206 (microRNA 1206, HGNC:35272) is a microRNA gene on chromosome 8q24.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302170 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35272
Approved symbol	MIR1206
Name	microRNA 1206
Location	8q24.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1206
Ensembl gene	ENSG00000283200
Ensembl biotype	miRNA
Entrez	100302170
RNAcentral	URS000075E581 — miRNA, 59 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637127

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637127 — 1 exons

Exon	Start	End
ENSE00003798184	128008898	128008956

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 69.46.

Top tissues by expression

3 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
multicellular organism	UBERON:0000468	69.46	gold quality
skin of abdomen	UBERON:0001416	64.51	gold quality
adrenal gland	UBERON:0002369	63.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The SNP within miR-1206 also affected expression of mature miR-1206, but not in a cell-type specific manner (PMID:23077621)
• Study replicates the finding that rs2114358 in miR-1206 is associated with the development of clinically relevant methotrexate-induced oral mucositis. (PMID:28628559)
• association of SNP rs2114358 in miR-1206 with the risk of Chronic Myeloid Leukemia patients, though more investigations are still required to understand the regulative mechanisms of this miR SNP with the target genes resulting in its dysregulation (PMID:30605069)
• Circ_0043256 upregulates KLF2 expression by absorbing miR-1206 to suppress the tumorigenesis of lung cancer. (PMID:36680456)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.