MIR1207

Summary

MIR1207 (microRNA 1207, HGNC:35273) is a microRNA gene on chromosome 8q24.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302175 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35273
Approved symbol	MIR1207
Name	microRNA 1207
Location	8q24.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1207
Ensembl gene	ENSG00000221176
Ensembl biotype	miRNA
Entrez	100302175
RNAcentral	URS000063AB20 — miRNA, 87 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408249

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408249 — 1 exons

Exon	Start	End
ENSE00001564884	128049152	128049238

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 80.19.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.19	gold quality
gastrocnemius	UBERON:0001388	76.50	gold quality
adrenal tissue	UBERON:0018303	75.51	gold quality
kidney	UBERON:0002113	74.53	gold quality
liver	UBERON:0002107	70.06	gold quality
colon	UBERON:0001155	69.87	gold quality
ascending aorta	UBERON:0001496	68.93	gold quality
left lobe of thyroid gland	UBERON:0001120	68.73	gold quality
body of stomach	UBERON:0001161	67.74	gold quality
right adrenal gland	UBERON:0001233	67.72	gold quality
right atrium auricular region	UBERON:0006631	67.72	gold quality
left adrenal gland	UBERON:0001234	67.56	gold quality
transverse colon	UBERON:0001157	67.33	gold quality
omental fat pad	UBERON:0010414	65.75	gold quality
body of uterus	UBERON:0009853	64.32	gold quality
stomach	UBERON:0000945	64.19	gold quality
skin of leg	UBERON:0001511	63.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.49	gold quality
right ovary	UBERON:0002118	62.94	gold quality
right lobe of thyroid gland	UBERON:0001119	62.13	gold quality
esophagus mucosa	UBERON:0002469	61.62	gold quality
prostate gland	UBERON:0002367	61.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	60.78	gold quality
ectocervix	UBERON:0012249	60.57	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.42	gold quality
skin of abdomen	UBERON:0001416	57.51	gold quality
minor salivary gland	UBERON:0001830	56.23	gold quality
upper lobe of left lung	UBERON:0008952	55.62	gold quality
left ovary	UBERON:0002119	54.02	gold quality
tibial nerve	UBERON:0001323	53.30	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 27)

• variant 1936T prevents hsa-miR-1207-5p from down-regulating HBEGF in podocytes (PMID:22319602)
• miR-1207-5p, a PVT1-derived microRNA, is abundantly expressed in kidney cells, and is upregulated by glucose and TGF-beta1. (PMID:24204837)
• MiR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting TERT. (PMID:24481448)
• miR-1207 plays a vital role in promoting the cancer stem cell-like phenotype in ovarian cancer by activating the Wnt/beta-catenin signaling pathway. (PMID:26337084)
• Data show that long noncoding RNA BC032469 could directly bind to miR-1207-5p and modulate the derepression of hTERT. (PMID:26549025)
• downregulation of miR-1207-5p and miR-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogren’s syndrome (PMID:26888739)
• miR-1207-5p and CSF1 expression levels and their relationship with lung cancer survival and metastasis status were assayed by means of a lung cancer tissue microarray. (PMID:27107415)
• our study suggests that miR12075p/FASN plays an important role in hepatocellular carcinoma (PMID:27461404)
• these studies have revealed a novel microRNA-1207-3p/FNDC1/FN1/AR regulatory pathway in prostate cancer. (PMID:27693493)
• A novel target of miR-1207-5p is identified heme oxygenase-1 mRNA by western blotting and Ago2 immunoprecipitation. knockdown of mir-1207-5p by miR-1207-5p mimic down-regulated heme oxygenase-1 gene expression. (PMID:28228215)
• PVT1-derived miR-1207-5p promotes the proliferation of breast cancer cells by targeting STAT6. (PMID:28235236)
• Downregulation of hsa-miR-208a-3p and hsa-miR-1207-5p may be involved in the occurrence of medulloblastoma (PMID:28481393)
• The Tyr113His T/C variant of rs1051740 and very slow phenotype alters EPHX1, miR-26b-5p and miR-1207-5p expression, and contributes towards low blood iron levels and low birthweights. (PMID:28789952)
• lower expression correlated with advanced stage and lymph node metastasis and shorter patient overall survival in colorectal cancer (PMID:29226644)
• Low expression of MIR1207 is associated with Nasopharyngeal Cancer. (PMID:30141114)
• Data found that miR-1207 expression was decreased in nasopharyngeal carcinoma (NPC) tissues, and LINC00319 facilitated cell proliferation in vitro via sponging miR-1207-5p in NPC cells. (PMID:30243935)
• Correlation between miR-1207-5p expression with steroid-induced necrosis of femoral head and VEGF expression. (PMID:31002120)
• CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal. (PMID:32046858)
• Characterization of antiapoptotic microRNAs in primary Sjogren’s syndrome. (PMID:32575162)
• MiR-1207-5p/CX3CR1 axis regulates the progression of osteoarthritis via the modulation of the activity of NF-kappaB pathway. (PMID:32597559)
• Plasma microRNA-1207-5p as a Potential Biomarker for Diagnosis and Prognosis of Colorectal Cancer. (PMID:32902212)
• miR-1207-5p Can Contribute to Dysregulation of Inflammatory Response in COVID-19 via Targeting SARS-CoV-2 RNA. (PMID:33194826)
• MiR-1207-5p targets PYCR1 to inhibit the progression of prostate cancer. (PMID:34461437)
• Long non-coding RNA LUADT1 promotes nasopharyngeal carcinoma cell proliferation and invasion by downregulating miR-1207-5p. (PMID:34738862)
• Down-regulation of lncRNA LUADT1 suppresses cervical cancer cell growth by sequestering microRNA-1207-5p. (PMID:35538030)
• LncRNA PVT1 Regulates miR-1207-5p to Affect Colon Cancer Proliferation and Migration via the Wnt6/beta-catenin2 Pathway. (PMID:35763386)
• Knockdown of LINC01138 protects human chondrocytes against IL-1beta-induced damage by regulating the hsa-miR-1207-5p/KIAA0101 axis. (PMID:36705420)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.