MIR1208

Summary

MIR1208 (microRNA 1208, HGNC:35274) is a microRNA gene on chromosome 8q24.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302281 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35274
Approved symbol	MIR1208
Name	microRNA 1208
Location	8q24.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1208
Ensembl gene	ENSG00000221261
Ensembl biotype	miRNA
Entrez	100302281
RNAcentral	URS00006A01F2 — miRNA, 73 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408334

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408334 — 1 exons

Exon	Start	End
ENSE00001564969	128150116	128150188

Expression profiles

Bgee: expression breadth broad, 66 present calls, max score 74.18.

Top tissues by expression

66 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	74.18	gold quality
blood	UBERON:0000178	74.16	gold quality
gastrocnemius	UBERON:0001388	73.98	gold quality
monocyte	CL:0000576	73.18	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.29	gold quality
putamen	UBERON:0001874	72.25	gold quality
smooth muscle tissue	UBERON:0001135	70.66	gold quality
lymph node	UBERON:0000029	69.80	gold quality
heart left ventricle	UBERON:0002084	69.00	gold quality
cerebellar hemisphere	UBERON:0002245	67.97	gold quality
endometrium	UBERON:0001295	67.67	gold quality
right adrenal gland cortex	UBERON:0035827	67.56	gold quality
tibial artery	UBERON:0007610	67.18	gold quality
Ammon’s horn	UBERON:0001954	67.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.98	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.97	gold quality
left coronary artery	UBERON:0001626	66.94	gold quality
heart	UBERON:0000948	66.84	gold quality
adrenal gland	UBERON:0002369	66.83	gold quality
anterior cingulate cortex	UBERON:0009835	66.60	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.37	gold quality
esophagus mucosa	UBERON:0002469	66.36	gold quality
colon	UBERON:0001155	66.22	gold quality
intestine	UBERON:0000160	66.07	gold quality
thoracic aorta	UBERON:0001515	65.72	gold quality
right frontal lobe	UBERON:0002810	65.69	gold quality
urinary bladder	UBERON:0001255	65.45	gold quality
minor salivary gland	UBERON:0001830	65.43	gold quality
ascending aorta	UBERON:0001496	65.37	gold quality
right atrium auricular region	UBERON:0006631	65.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• These findings suggest that miR-1208 acts as a tumor suppressor and targets TBCK directly, thus possessing great potential for use in renal cancer therapy. (PMID:31331056)
• Silencing circPVT1 enhances radiosensitivity in non-small cell lung cancer by sponging microRNA-1208. (PMID:33896835)
• HAND2-AS1 targeting miR-1208/SIRT1 axis alleviates foam cell formation in atherosclerosis. (PMID:34780888)
• Genetic polymorphisms in MIR1208 and MIR5708 are associated with susceptibility to COPD in the Chinese population. (PMID:36115827)
• Focused ultrasound combined with miR-1208-equipped exosomes inhibits malignant progression of glioma. (PMID:37580442)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.