MIR1224

Summary

MIR1224 (microRNA 1224, HGNC:33923) is a microRNA gene on chromosome 3q27.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100187716 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33923
Approved symbol	MIR1224
Name	microRNA 1224
Location	3q27.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1224
Ensembl gene	ENSG00000221120
Ensembl biotype	miRNA
OMIM	611620
Entrez	100187716
RNAcentral	URS00006378D3 — miRNA, 85 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408193

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408193 — 1 exons

Exon	Start	End
ENSE00001564828	184241405	184241489

Expression profiles

Bgee: expression breadth broad, 67 present calls, max score 94.83.

Top tissues by expression

67 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.83	gold quality
gastrocnemius	UBERON:0001388	73.68	gold quality
right adrenal gland	UBERON:0001233	73.55	gold quality
adrenal gland	UBERON:0002369	72.53	gold quality
heart left ventricle	UBERON:0002084	72.31	gold quality
body of pancreas	UBERON:0001150	71.65	gold quality
left adrenal gland	UBERON:0001234	71.55	gold quality
blood	UBERON:0000178	71.32	gold quality
liver	UBERON:0002107	70.98	gold quality
right adrenal gland cortex	UBERON:0035827	70.91	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.89	gold quality
heart	UBERON:0000948	69.92	gold quality
right lobe of liver	UBERON:0001114	69.66	gold quality
cerebellar hemisphere	UBERON:0002245	69.57	gold quality
left adrenal gland cortex	UBERON:0035825	69.54	gold quality
body of stomach	UBERON:0001161	68.95	gold quality
right atrium auricular region	UBERON:0006631	68.93	gold quality
amygdala	UBERON:0001876	68.16	gold quality
right frontal lobe	UBERON:0002810	68.13	gold quality
frontal cortex	UBERON:0001870	68.09	gold quality
stomach	UBERON:0000945	67.74	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.71	gold quality
tibial artery	UBERON:0007610	67.27	gold quality
endometrium	UBERON:0001295	66.94	gold quality
ascending aorta	UBERON:0001496	66.85	gold quality
lung	UBERON:0002048	66.85	gold quality
brain	UBERON:0000955	66.65	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.30	gold quality
anterior cingulate cortex	UBERON:0009835	66.22	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 21)

• These data indicate that miR-1224-5p may inhibit tumor-associated activity in malignant gliomas by targeting CREB1. (PMID:25648114)
• miR-1224 is a previously unrecognised regulator of proliferation after Acute Liver Failure in hepatocytes and represents a novel and specific biomarker of liver injury with prognostic value in Acute Liver Failure. (PMID:28645739)
• MiR-1224 is a specific modulator of angiogenesis. EPN2 mRNA is a direct target of miR-1224 (PMID:28717225)
• Overexpression of miR-1224-5p led to inhibition of keloid fibroblast proliferation, promotion of apoptosis and decrease of migration and invasion. Our results suggest that downregulation of miR-1224-5p may be one of the mechanisms involved in the occurrence and development of keloids. (PMID:29050938)
• Findings indicate that miR-1224-5p promotes hepatic lipogenesis by suppressing AMPKalpha1 expression. (PMID:29474539)
• infection with Bacillus Calmette-Guerin resulted in an increase in miR-1224 expression in monocyte-derived macrophages (PMID:29908542)
• that upregulation in miR-1224-5p expression may decrease proliferation, induce apoptosis, inhibit migration and invasion, and suppress tube formation in TECs of human HCC. MiR-1224-5p may serve as a potential tumor suppressor in HCC. (PMID:30964106)
• Low expression of miR1224 is associated with osteosarcoma progression. (PMID:31419446)
• LncRNA NEAT1/miR-1224/KLF3 contributes to cell proliferation, apoptosis and invasion in lung cancer. (PMID:31646570)
• Low miR1224 expression is associated with papillomavirus-infected laryngeal papillomas. (PMID:32002629)
• LncRNA MIR4435-2HG potentiates the proliferation and invasion of glioblastoma cells via modulating miR-1224-5p/TGFBR2 axis. (PMID:32319715)
• LncRNA linc00460 sponges miR-1224-5p to promote esophageal cancer metastatic potential and epithelial-mesenchymal transition. (PMID:32534700)
• MiR-1224-5p acts as a tumor suppressor via inhibiting the malignancy of rectal cancer through targeting SLC29A3. (PMID:32738187)
• Circular RNA EGLN3 silencing represses renal cell carcinoma progression through the miR-1224-3p/HMGXB3 axis. (PMID:34274607)
• Exosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis. (PMID:34546854)
• MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1. (PMID:34637688)
• Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Analyses. (PMID:35678909)
• MicroRNA-1224-5p Aggravates Sepsis-Related Acute Lung Injury in Mice. (PMID:35799888)
• Long Non-coding RNA SPAG5-AS1 Attenuates Diabetic Retinal Vascular Dysfunction by Inhibiting Human Retinal Microvascular Endothelial Cell Proliferation, Migration, and Tube Formation by Regulating the MicroRNA-1224-5p/IRS-1 Axis. (PMID:36346578)
• Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p. (PMID:36918335)
• CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis. (PMID:38312030)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir1224	ENSMUSG00000080669

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.