MIR1225

Summary

MIR1225 (microRNA 1225, HGNC:33931) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100188847 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33931
Approved symbol	MIR1225
Name	microRNA 1225
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1225
Ensembl gene	ENSG00000221656
Ensembl biotype	miRNA
OMIM	611621
Entrez	100188847
RNAcentral	URS00006DAE80 — miRNA, 90 nt, 20 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408729

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408729 — 1 exons

Exon	Start	End
ENSE00001565364	2090195	2090284

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 98.34.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.34	gold quality
skeletal muscle tissue	UBERON:0001134	85.07	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.91	gold quality
liver	UBERON:0002107	77.49	gold quality
muscle of leg	UBERON:0001383	76.19	gold quality
placenta	UBERON:0001987	75.60	gold quality
blood	UBERON:0000178	75.07	gold quality
gastrocnemius	UBERON:0001388	74.51	gold quality
myometrium	UBERON:0001296	72.09	gold quality
descending thoracic aorta	UBERON:0002345	69.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.17	gold quality
stomach	UBERON:0000945	69.03	gold quality
left adrenal gland cortex	UBERON:0035825	68.91	gold quality
endometrium	UBERON:0001295	68.90	gold quality
body of stomach	UBERON:0001161	68.80	gold quality
heart left ventricle	UBERON:0002084	68.70	gold quality
adrenal gland	UBERON:0002369	68.07	gold quality
body of pancreas	UBERON:0001150	67.72	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.31	gold quality
thoracic aorta	UBERON:0001515	67.30	gold quality
left coronary artery	UBERON:0001626	67.25	gold quality
fundus of stomach	UBERON:0001160	67.20	gold quality
Ammon’s horn	UBERON:0001954	67.12	gold quality
right lobe of liver	UBERON:0001114	67.08	gold quality
ascending aorta	UBERON:0001496	67.08	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.87	gold quality
left ovary	UBERON:0002119	66.62	gold quality
ectocervix	UBERON:0012249	66.61	gold quality
esophagus	UBERON:0001043	66.57	gold quality
transverse colon	UBERON:0001157	66.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• miR-1915 and miR-1225-5p regulated the expression of important markers of renal progenitors, such as CD133 and PAX2, and important genes involved in the repair mechanisms of adult renal progenitor cells, such as TLR2. (PMID:23861881)
• Findings suggest that microRNAs miR-21 and miR-1225-5p may serve as biomarkers of peritoneal recurrence after curative gastric cancer (GC) resection. (PMID:26208314)
• Downregulation of miR-1225-5p was associated with metastasis of gastric carcinoma. (PMID:26684358)
• Results show that serum hsa-miR-122-5p may function as a new biomarker for liver injury in patients with normal ALT levels. This biomarker may make it possible identify a subset of patients who are experiencing liver injury but have normal ALT levels. (PMID:29881991)
• miR-1225 targets CDC14B 3’-UTR and recovery of CDC14B expression counteracted the suppressive influence of miR-1225 on laryngeal cancer cells (PMID:30138106)
• Expression of miR-1225 was upregulated in pancreatic cancer cells and in specimens from patients suffering from pancreatic cancer. MiR-1225 inhibition impaired the proliferation of pancreatic cancer cells in vitro and in vivo and suppressed the tumor growth. (PMID:30990343)
• MicroRNA-1225-5p inhibits the development and progression of thyroid cancer via targeting sirtuin 3. (PMID:31288899)
• Data confirmed that SOX9 transcription factor (Sox9) is the target gene of miR-1225-5p. (PMID:31765229)
• Downregulation of miR-1225-5p is pivotal for proliferation, invasion, and migration of HCC cells through NFkappaB regulation. (PMID:32720731)
• Functional classification of prostate cancerassociated miRNAs through CRISPR/Cas9mediated gene knockout. (PMID:32901864)
• Overexpression of miR-1225 promotes the progression of breast cancer, resulting in poor prognosis. (PMID:33423149)
• Long non-coding RNA DANCR promoted non-small cell lung cancer cells metastasis via modulating of miR-1225-3p/ErbB2 signal. (PMID:33577030)
• The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer. (PMID:36178207)
• MicroRNA-122-5p alleviates endometrial fibrosis via inhibiting the TGF-beta/SMAD pathway in Asherman’s syndrome. (PMID:37677924)
• Hypoxic tumour-derived exosomal miR-1225-5p regulates M2 macrophage polarisation via toll-like receptor 2 to promote ovarian cancer progress. (PMID:38010845)
• MicroRNA-1225-5p Promotes the Development of Fibrotic Cataracts via Keap1/Nrf2 Signaling. (PMID:38450708)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Gm54763	ENSMUSG00002076170

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.