MIR1226

Summary

MIR1226 (microRNA 1226, HGNC:33922) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302232 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33922
Approved symbol	MIR1226
Name	microRNA 1226
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1226
Ensembl gene	ENSG00000221585
Ensembl biotype	miRNA
Entrez	100302232
RNAcentral	URS000064B9B1 — miRNA, 75 nt, 20 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408658

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408658 — 1 exons

Exon	Start	End
ENSE00001565293	47849555	47849629

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 84.21.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	84.21	gold quality
calcaneal tendon	UBERON:0003701	83.46	gold quality
monocyte	CL:0000576	79.39	gold quality
granulocyte	CL:0000094	77.44	gold quality
adrenal tissue	UBERON:0018303	75.86	gold quality
gall bladder	UBERON:0002110	73.72	gold quality
endometrium	UBERON:0001295	72.72	gold quality
islet of Langerhans	UBERON:0000006	72.13	gold quality
gastrocnemius	UBERON:0001388	71.55	gold quality
blood	UBERON:0000178	71.18	gold quality
left uterine tube	UBERON:0001303	70.32	gold quality
left adrenal gland cortex	UBERON:0035825	70.09	gold quality
tonsil	UBERON:0002372	70.04	gold quality
heart left ventricle	UBERON:0002084	69.32	gold quality
body of pancreas	UBERON:0001150	68.82	gold quality
heart	UBERON:0000948	68.77	gold quality
stomach	UBERON:0000945	68.68	gold quality
right lobe of liver	UBERON:0001114	68.42	gold quality
body of stomach	UBERON:0001161	68.16	gold quality
right atrium auricular region	UBERON:0006631	68.05	gold quality
lymph node	UBERON:0000029	68.03	gold quality
liver	UBERON:0002107	67.95	gold quality
myometrium	UBERON:0001296	67.76	gold quality
tibial artery	UBERON:0007610	67.75	gold quality
descending thoracic aorta	UBERON:0002345	67.70	gold quality
thoracic aorta	UBERON:0001515	67.36	gold quality
adult mammalian kidney	UBERON:0000082	67.35	gold quality
left adrenal gland	UBERON:0001234	67.30	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.30	gold quality
ascending aorta	UBERON:0001496	67.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• MIR-1226 functions as a tumor suppressor by promoting the induction of cell death. (PMID:20514397)
• Within the limitations of the present study, it may be concluded that miR-1226 can be a promising biomarker for periodontal disease, adding relevant information to common clinical parameters used for diagnosis and prognosis of periodontitis (PMID:29680855)
• MiR210HG sponges miR-1226-3p to facilitate invasive breast cancer cell invasion and metastasis by regulating mucin-1c and EMT pathway (PMID:31399552)
• Cell specific tumor suppressor effect of Hsa-miR-1226-3p through downregulation of HER2, PIK3R2, and AKT1 genes. (PMID:33675995)
• The expression and clinical significance of miR-1226 in patients with periodontitis. (PMID:34592963)
• MiR-1226, mediated by ASCL1, suppresses the progression of non-small cell lung cancer by targeting FGF2. (PMID:35164915)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.