MIR1227

Summary

MIR1227 (microRNA 1227, HGNC:33932) is a microRNA gene on chromosome 19p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302283 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33932
Approved symbol	MIR1227
Name	microRNA 1227
Location	19p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1227
Ensembl gene	ENSG00000221411
Ensembl biotype	miRNA
Entrez	100302283
RNAcentral	URS00006DE17B — miRNA, 88 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408484

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408484 — 1 exons

Exon	Start	End
ENSE00001565119	2234062	2234149

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 84.14.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	84.14	gold quality
duodenum	UBERON:0002114	80.06	gold quality
monocyte	CL:0000576	76.14	gold quality
islet of Langerhans	UBERON:0000006	74.97	gold quality
muscle of leg	UBERON:0001383	74.07	gold quality
blood	UBERON:0000178	73.45	gold quality
lymph node	UBERON:0000029	73.07	gold quality
gastrocnemius	UBERON:0001388	72.94	gold quality
prefrontal cortex	UBERON:0000451	72.31	gold quality
body of stomach	UBERON:0001161	71.39	gold quality
right atrium auricular region	UBERON:0006631	71.20	gold quality
left adrenal gland cortex	UBERON:0035825	70.98	gold quality
endometrium	UBERON:0001295	70.52	gold quality
heart	UBERON:0000948	69.82	gold quality
right lobe of liver	UBERON:0001114	69.43	gold quality
heart left ventricle	UBERON:0002084	69.30	gold quality
left adrenal gland	UBERON:0001234	69.08	gold quality
body of pancreas	UBERON:0001150	68.81	gold quality
liver	UBERON:0002107	68.70	gold quality
tibial artery	UBERON:0007610	68.40	gold quality
transverse colon	UBERON:0001157	68.08	gold quality
colon	UBERON:0001155	67.23	gold quality
left uterine tube	UBERON:0001303	67.17	gold quality
minor salivary gland	UBERON:0001830	67.07	gold quality
ascending aorta	UBERON:0001496	66.58	gold quality
rectum	UBERON:0001052	66.43	gold quality
small intestine	UBERON:0002108	66.19	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.09	gold quality
right adrenal gland	UBERON:0001233	66.06	gold quality
substantia nigra	UBERON:0002038	65.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-1227-3p participates in the development of fetal growth restriction via regulating trophoblast cell proliferation and apoptosis. (PMID:35430618)
• Circular RNA circ_0114876 regulates osteoarthritis through upregulating ADAM10 via targeting miR-1227-3p. (PMID:36436795)
• Long noncoding RNA KCNMA1-AS2 regulates the function of colorectal cancer cells and sponges miR-1227-5p. (PMID:39026221)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.