MIR122HG

Summary

MIR122HG (MIR122 host gene, HGNC:53821) is a long non-coding RNA gene on chromosome 18q21.31.

Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex.

Source: NCBI Gene 112441433 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53821
Approved symbol	MIR122HG
Name	MIR122 host gene
Location	18q21.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	lnc-pri-miR-122
Ensembl gene	ENSG00000267391
Ensembl biotype	lncRNA
Entrez	112441433
RNAcentral	URS0002123229 — lncRNA, 421 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000590797, ENST00000655521, ENST00000656883, ENST00000667453, ENST00000686745, ENST00000689108, ENST00000693559, ENST00000701002, ENST00000768700, ENST00000768701, ENST00000768702

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000590797 — 2 exons

Exon	Start	End
ENSE00004129195	58445864	58446337
ENSE00004129197	58449309	58453766

Expression profiles

Bgee: expression breadth broad, 47 present calls, max score 86.76.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.0161 / max 319.4939, expressed in 66 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
170409	1.0161	66

Top tissues by expression

168 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	86.76	gold quality
right lobe of liver	UBERON:0001114	82.78	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	82.40	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	79.60	gold quality
buccal mucosa cell	CL:0002336	79.54	gold quality
biceps brachii	UBERON:0001507	78.60	gold quality
nasal cavity epithelium	UBERON:0005384	75.69	gold quality
skeletal muscle tissue	UBERON:0001134	75.44	silver quality
vastus lateralis	UBERON:0001379	75.31	gold quality
quadriceps femoris	UBERON:0001377	75.17	gold quality
deltoid	UBERON:0001476	74.02	gold quality
heart right ventricle	UBERON:0002080	73.89	gold quality
endothelial cell	CL:0000115	73.14	gold quality
tendon of biceps brachii	UBERON:0008188	70.67	silver quality
substantia nigra pars reticulata	UBERON:0001966	70.50	gold quality
tendon	UBERON:0000043	70.15	gold quality
sperm	CL:0000019	70.06	gold quality
subthalamic nucleus	UBERON:0001906	69.95	gold quality
lateral globus pallidus	UBERON:0002476	69.19	gold quality
gingival epithelium	UBERON:0001949	69.05	gold quality
vena cava	UBERON:0004087	68.53	gold quality
dorsal plus ventral thalamus	UBERON:0001897	68.29	gold quality
lateral nuclear group of thalamus	UBERON:0002736	68.25	gold quality
cerebellar vermis	UBERON:0004720	68.19	gold quality
metanephros	UBERON:0000081	68.12	gold quality
gingiva	UBERON:0001828	67.52	gold quality
pharyngeal mucosa	UBERON:0000355	67.35	gold quality
inferior vagus X ganglion	UBERON:0005363	67.09	gold quality
hypothalamus	UBERON:0001898	67.02	gold quality
ventral tegmental area	UBERON:0002691	66.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The long noncoding RNA MIR122HG is a precursor for miR-122-5p and negatively regulates the TAK1-induced innate immune response in teleost fish. (PMID:35218771)
• Protective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury. (PMID:36424455)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.