MIR1231

Summary

MIR1231 (microRNA 1231, HGNC:33921) is a microRNA gene on chromosome 1q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302158 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33921
Approved symbol	MIR1231
Name	microRNA 1231
Location	1q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1231
Ensembl gene	ENSG00000221028
Ensembl biotype	miRNA
OMIM	617040
Entrez	100302158
RNAcentral	URS000075A358 — miRNA, 92 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408101

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408101 — 1 exons

Exon	Start	End
ENSE00001564736	201808611	201808702

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 94.54.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	94.54	gold quality
islet of Langerhans	UBERON:0000006	74.88	gold quality
muscle of leg	UBERON:0001383	74.80	gold quality
gastrocnemius	UBERON:0001388	74.39	gold quality
body of pancreas	UBERON:0001150	73.53	gold quality
adrenal tissue	UBERON:0018303	72.88	gold quality
apex of heart	UBERON:0002098	72.32	gold quality
heart left ventricle	UBERON:0002084	70.93	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.80	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	70.44	gold quality
smooth muscle tissue	UBERON:0001135	69.95	gold quality
heart	UBERON:0000948	69.91	gold quality
ascending aorta	UBERON:0001496	68.99	gold quality
thoracic aorta	UBERON:0001515	68.99	gold quality
descending thoracic aorta	UBERON:0002345	68.49	gold quality
tibial artery	UBERON:0007610	67.69	gold quality
fundus of stomach	UBERON:0001160	67.58	gold quality
stomach	UBERON:0000945	67.21	gold quality
body of stomach	UBERON:0001161	67.04	gold quality
right atrium auricular region	UBERON:0006631	67.01	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.93	gold quality
left coronary artery	UBERON:0001626	66.77	gold quality
substantia nigra	UBERON:0002038	66.64	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.47	gold quality
right adrenal gland	UBERON:0001233	66.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.27	gold quality
esophagus	UBERON:0001043	66.13	gold quality
skin of abdomen	UBERON:0001416	66.09	gold quality
caudate nucleus	UBERON:0001873	66.06	gold quality
left adrenal gland	UBERON:0001234	66.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• common genetic changes in IFNAR1 may influence HCC risk, likely through miR-1231-mediated regulation. (PMID:22824466)
• In conclusion, a novel interaction between hsa-miR-1231 and hepatitis B virus replication was identified. (PMID:24835118)
• Decreased miR-1231 expression was significantly associated with advanced tumor grade, progression-free survival and overall survival. (PMID:30556881)
• The downregulation of exosomal miR-1231 in plasma of pancreatic cancer patients and pancreatic cancer cells suggests that it is related to the initiation and development of pancreatic cancer. It may be a new diagnostic and prognostic marker for pancreatic cancer. (PMID:30678416)
• circ_0025033 RNA, miR-1231, and miR-1304 are involved in parathyroid cancer initiation and progression (PMID:30709584)
• Data show that circular RNA circ-DCAF6 (DDB1 and CUL4 associated factor 6) exerts oncogenic properties by downregulating miR-1231 and miR-1256. (PMID:31226266)
• A novel circRNA in BC progression, hsa_circ_0137606, could suppress BC proliferation and metastasis by sponging miR1231. (PMID:31545480)
• Low miR-1231 expression is associated with Prostate Cancer. (PMID:31822000)
• MiR-1231 correlates tumor prognosis and inhibits cell growth in ovarian cancer. (PMID:32894537)
• MiR-1231 enhances docetaxel sensitivity to gallbladder carcinoma cells by downregulating FOXC2. (PMID:33336729)
• Circular RNA hsa_Circ_0005795 mediates cell proliferation of cutaneous basal cell carcinoma via sponging miR-1231. (PMID:33433717)
• Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer. (PMID:34153004)
• Upregulated circ_0002141 facilitates oral squamous cell carcinoma progression via the miR-1231/EGFR axis. (PMID:34739167)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.