MIR1233-2

Summary

MIR1233-2 (microRNA 1233-2, HGNC:38277) is a microRNA gene on chromosome 15q14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422845 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38277
Approved symbol	MIR1233-2
Name	microRNA 1233-2
Location	15q14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1233-2
Ensembl gene	ENSG00000221065
Ensembl biotype	miRNA
Entrez	100422845
RNAcentral	URS0000759F8D — miRNA, 82 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408138

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408138 — 1 exons

Exon	Start	End
ENSE00001808484	34528290	34528371

Expression profiles

Bgee: expression breadth broad, 90 present calls, max score 74.37.

Top tissues by expression

90 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	74.37	gold quality
blood	UBERON:0000178	72.32	gold quality
lymph node	UBERON:0000029	71.75	gold quality
monocyte	CL:0000576	71.65	gold quality
islet of Langerhans	UBERON:0000006	70.75	gold quality
liver	UBERON:0002107	69.48	gold quality
muscle of leg	UBERON:0001383	69.18	gold quality
gastrocnemius	UBERON:0001388	68.34	gold quality
rectum	UBERON:0001052	67.53	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	65.63	gold quality
heart left ventricle	UBERON:0002084	65.18	gold quality
body of pancreas	UBERON:0001150	65.06	gold quality
right atrium auricular region	UBERON:0006631	64.96	gold quality
right lobe of liver	UBERON:0001114	64.94	gold quality
right lobe of thyroid gland	UBERON:0001119	64.67	gold quality
heart	UBERON:0000948	64.57	gold quality
calcaneal tendon	UBERON:0003701	64.51	gold quality
placenta	UBERON:0001987	64.37	gold quality
left lobe of thyroid gland	UBERON:0001120	64.02	gold quality
smooth muscle tissue	UBERON:0001135	63.71	gold quality
prefrontal cortex	UBERON:0000451	63.65	gold quality
endometrium	UBERON:0001295	63.37	gold quality
thyroid gland	UBERON:0002046	63.02	gold quality
left uterine tube	UBERON:0001303	62.97	gold quality
granulocyte	CL:0000094	62.50	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.48	gold quality
left ovary	UBERON:0002119	62.40	gold quality
tibial artery	UBERON:0007610	62.37	gold quality
popliteal artery	UBERON:0002250	62.34	gold quality
stomach	UBERON:0000945	61.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miRNA-1233 differentiated acute pulmonary embolism from non ST-segment elevation myocardial infarction patients and healthy individuals. (PMID:27150028)
• These results suggest that rs1054564 confers allele-specific translational repression of GDF15 via hsa-miR-1233-3p. (PMID:28806401)
• The Predictive Value of microRNA-134 and microRNA-1233 for the Early Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Acute Pulmonary Embolism. (PMID:33116466)

Cross-species orthologs

0 orthologs

Paralogs (1): MIR1233-1 (ENSG00000221649)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.