MIR1236

Summary

MIR1236 (microRNA 1236, HGNC:33925) is a microRNA gene on chromosome 6p21.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302242 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33925
Approved symbol	MIR1236
Name	microRNA 1236
Location	6p21.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1236
Ensembl gene	ENSG00000284446
Ensembl biotype	miRNA
Entrez	100302242
RNAcentral	URS000075C764 — miRNA, 102 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408340

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408340 — 1 exons

Exon	Start	End
ENSE00001564975	31956839	31956940

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 88.14.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	88.14	gold quality
liver	UBERON:0002107	73.64	gold quality
right lobe of liver	UBERON:0001114	73.63	gold quality
gastrocnemius	UBERON:0001388	73.47	gold quality
stomach	UBERON:0000945	71.28	gold quality
heart left ventricle	UBERON:0002084	70.84	gold quality
heart	UBERON:0000948	70.72	gold quality
body of pancreas	UBERON:0001150	69.98	gold quality
right atrium auricular region	UBERON:0006631	69.25	gold quality
fundus of stomach	UBERON:0001160	69.04	gold quality
ascending aorta	UBERON:0001496	69.02	gold quality
multicellular organism	UBERON:0000468	68.04	gold quality
anterior cingulate cortex	UBERON:0009835	67.69	gold quality
body of stomach	UBERON:0001161	67.65	gold quality
left adrenal gland	UBERON:0001234	67.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.26	gold quality
vagina	UBERON:0000996	67.03	gold quality
right lobe of thyroid gland	UBERON:0001119	66.88	gold quality
left coronary artery	UBERON:0001626	66.61	gold quality
right ovary	UBERON:0002118	66.35	gold quality
putamen	UBERON:0001874	66.33	gold quality
endometrium	UBERON:0001295	66.25	gold quality
adrenal gland	UBERON:0002369	66.25	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.33	gold quality
skin of abdomen	UBERON:0001416	65.16	gold quality
omental fat pad	UBERON:0010414	64.85	gold quality
nucleus accumbens	UBERON:0001882	64.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.58	gold quality
cerebral cortex	UBERON:0000956	64.45	gold quality
transverse colon	UBERON:0001157	64.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 30)

• Suggest that miR-1236 may function as a negative regulator of VEGFR-3 signaling during inflammatory lymphangiogenesis. (PMID:22223733)
• our results indicate that miR-1236-3p regulates ovarian cancer metastasis by directly targeting ZEB1 (PMID:24573236)
• VprBP transcription was repressed by cellular miRNA-1236, which contributes to HIV-1 restriction in monocytes. miR-1236 inhibitors enhanced translation of VprBP and promoted infection. miR-1236 mimetics suppressed translation of VprBP. (PMID:24932481)
• miRNA1236 regulates hypoxia-induced epithelial-mesenchymal transformation and metastasis by repressing HDAC3 and SENP1 expression. (PMID:27177472)
• miR-1236 can reduce hepatitis B virus (HBV) replication and protein production by directly targeting HBV specific mRNA. (PMID:27734898)
• Overexpression of these two microRNAs in A549 induced cell-cycle arrest and cell senescence, delayed cell proliferation and colony formation, and inhibited migration and invasion. In conclusion, microRNA-mediated RNAa depends on the cell context, and miR-1236 and miR-370 can inhibit non-small-cell lung carcinoma cell growth by upregulating p21 expression in vitro (PMID:28631573)
• expression of miR-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue; in A549 cell line, miR-1236-3p decreased ability of cell invasion and migration; furthermore, KLF8 is targeted by miR-1236-3p, and expression of miR-1236-3p is negatively correlated with KLF8; additionally, miR-1236-3p suppressed the expression of KLF8 and EMT (epithelial mesenchymal transition)-related genes (PMID:28842254)
• LncRNA FAL1 promotes cell proliferation and migration by acting as a CeRNA of miR-1236 in hepatocellular carcinoma cells. (PMID:29421439)
• Results identified that microRNA 1236 target the 3’UTR of FEN1 and regulates its expression. (PMID:30260965)
• Study found that miR-1236 was significantly downregulated in gastric cancer (GC) tissues and associated clinical stage, lymph node metastasis and poor survival of GC patients suggesting that mi-R1236 low expression may be a significant prognostic factor. (PMID:30280772)
• hsa_circ_0074362 plays a crucial role in glioma progression by regulating the miR-1236-3p/HOXB7 pathway. (PMID:30388035)
• Tumor-promoting effect was inhibited after we transfected miR-1236-3p into circ-CSPP1 overexpressing OC cells. (PMID:30965236)
• The findings indicated the regulatory association of miR-1236 with TLR4 and the abnormal expression of TLR4 caused by the presence of rs11536889 in the 3’-untranslated region of mRNA, which interfere with its interaction with the miR-1236, contributing to the risk of ventilator-associated pneumonia. (PMID:30972742)
• Circular RNA circ_001350 regulates glioma cell proliferation, apoptosis, and metastatic properties by acting as a miRNA sponge. (PMID:31020693)
• The study showed that miR-1236-3p is downregulated in GC tissues, and low expression of miR-1236-3p is associated with a poor prognosis in GC. It may be a new diagnostic and prognostic biomarker for GC. (PMID:31045511)
• Circular RNA circ_0103552 forecasts dismal prognosis and promotes breast cancer cell proliferation and invasion by sponging miR-1236. (PMID:31056795)
• Upregulated miRNA-1236-3p in osteosarcoma inhibits cell proliferation and induces apoptosis via targeting KLF8. (PMID:31364106)
• MicroRNA-1236-3p inhibits proliferation and invasion of breast cancer cells by targeting ZEB1. (PMID:31799668)
• microRNA-1236 promotes chondrocyte apoptosis in osteoarthritis via direct suppression of PIK3R3 (PMID:32325132)
• CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR12363p in cutaneous squamous cell carcinoma. (PMID:32626939)
• lncRNA FEZF1AS1 promotes migration, invasion and epithelialmesenchymal transition of retinoblastoma cells by targeting miR12363p. (PMID:32901841)
• Knockdown of circ_0006528 Suppresses Cell Proliferation, Migration, Invasion, and Adriamycin Chemoresistance via Regulating the miR-1236-3p/CHD4 Axis in Breast Cancer. (PMID:33333383)
• Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis. (PMID:33728810)
• circ_0101802 functions as a sponge of miR-1236-3p to facilitate the proliferation, migration and invasion of colorectal cancer via regulating MACC1. (PMID:34294360)
• circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma. (PMID:34526098)
• LINC00839 Promotes the Progression of Gastric Cancer by Sponging miR-1236-3p. (PMID:35622250)
• Molecular mechanisms of miR-1236 in the assessment of tumor lymphangiogenesis in human ovarian cancer patients. (PMID:36750632)
• VEGFR3 suppression through miR-1236 inhibits proliferation and induces apoptosis in ovarian cancer via ERK1/2 and AKT signaling pathways. (PMID:36922713)
• Regulation of Cervical Cancer Development by a Novel Circ_0000212/miR-1236-3p/GREM1 ceRNA Crosstalk. (PMID:36952219)
• Elevated TFPI is a prognostic factor in hepatocellular carcinoma: Putative role of miR-7-5p and miR-1236-3p. (PMID:38945092)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.