MIR1237

Summary

MIR1237 (microRNA 1237, HGNC:33927) is a microRNA gene on chromosome 11q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302280 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33927
Approved symbol	MIR1237
Name	microRNA 1237
Location	11q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1237
Ensembl gene	ENSG00000221273
Ensembl biotype	miRNA
Entrez	100302280
RNAcentral	URS000063ACDB — miRNA, 102 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408346

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408346 — 1 exons

Exon	Start	End
ENSE00001564981	64368602	64368703

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 77.76.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	77.76	gold quality
bone marrow	UBERON:0002371	76.91	gold quality
blood	UBERON:0000178	76.42	gold quality
body of stomach	UBERON:0001161	76.41	gold quality
monocyte	CL:0000576	75.22	gold quality
muscle of leg	UBERON:0001383	73.99	gold quality
right lobe of liver	UBERON:0001114	73.10	gold quality
nucleus accumbens	UBERON:0001882	72.70	gold quality
anterior cingulate cortex	UBERON:0009835	70.82	gold quality
left adrenal gland cortex	UBERON:0035825	70.57	gold quality
gastrocnemius	UBERON:0001388	70.51	gold quality
right frontal lobe	UBERON:0002810	70.47	gold quality
left coronary artery	UBERON:0001626	69.65	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.69	gold quality
ascending aorta	UBERON:0001496	67.98	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.92	gold quality
endometrium	UBERON:0001295	67.79	gold quality
right atrium auricular region	UBERON:0006631	67.59	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.55	gold quality
skin of leg	UBERON:0001511	67.13	gold quality
adult mammalian kidney	UBERON:0000082	66.89	gold quality
esophagus mucosa	UBERON:0002469	66.70	gold quality
putamen	UBERON:0001874	66.57	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.12	gold quality
skin of abdomen	UBERON:0001416	65.61	gold quality
omental fat pad	UBERON:0010414	65.57	gold quality
transverse colon	UBERON:0001157	65.48	gold quality
minor salivary gland	UBERON:0001830	64.90	gold quality
hypothalamus	UBERON:0001898	64.79	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.80	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Reduced miR-1237-3p expression was associated with chordoma invasion and worse recurrence-free survival of the patients. (PMID:25850393)
• Results showed that MIR219-2, MIR663b and MIR1237 were transcriptionally silenced by DNA hypermethylation in human gastric cancer cell lines. (PMID:26043902)
• Two novel DMRs, located in RPS6KA4/MIR1237 and the AURKC promoter, were found to be hypermethylated in WT (PMID:28930610)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.