MIR1238

Summary

MIR1238 (microRNA 1238, HGNC:33933) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302226 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33933
Approved symbol	MIR1238
Name	microRNA 1238
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1238
Ensembl gene	ENSG00000221410
Ensembl biotype	miRNA
Entrez	100302226
RNAcentral	URS000075A0EE — miRNA, 83 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408483

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408483 — 1 exons

Exon	Start	End
ENSE00001565118	10552122	10552204

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 79.55.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	79.55	gold quality
adrenal tissue	UBERON:0018303	74.89	gold quality
granulocyte	CL:0000094	73.74	gold quality
blood	UBERON:0000178	73.51	gold quality
monocyte	CL:0000576	73.28	gold quality
gastrocnemius	UBERON:0001388	72.66	gold quality
fundus of stomach	UBERON:0001160	70.82	gold quality
endometrium	UBERON:0001295	70.61	gold quality
lymph node	UBERON:0000029	69.75	gold quality
heart left ventricle	UBERON:0002084	69.49	gold quality
left adrenal gland cortex	UBERON:0035825	68.87	gold quality
right lobe of liver	UBERON:0001114	68.23	gold quality
left adrenal gland	UBERON:0001234	67.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.57	gold quality
right adrenal gland	UBERON:0001233	67.45	gold quality
body of stomach	UBERON:0001161	67.39	gold quality
tibial artery	UBERON:0007610	67.33	gold quality
right atrium auricular region	UBERON:0006631	67.24	gold quality
hypothalamus	UBERON:0001898	66.55	gold quality
right ovary	UBERON:0002118	66.46	gold quality
descending thoracic aorta	UBERON:0002345	66.36	gold quality
left coronary artery	UBERON:0001626	66.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.09	gold quality
transverse colon	UBERON:0001157	65.73	gold quality
Ammon’s horn	UBERON:0001954	65.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.34	gold quality
caudate nucleus	UBERON:0001873	65.01	gold quality
putamen	UBERON:0001874	64.97	gold quality
skin of leg	UBERON:0001511	64.78	gold quality
thoracic aorta	UBERON:0001515	64.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 10)

• Findings demonstrate that miR-1238 inhibit the proliferation of NSCLC cells at least partly via repression of LHX2, shedding light on the mechanistic interaction of miR-1238 and LHX2 in NSCLC carcinogenesis. (PMID:26189214)
• study determined that reduced expression of miR-139-3p, miR-6069, and miR-494 and induced expression of miR-1238-3p were significantly associated with chronic brucellosis (PMID:27722176)
• These results suggest that circulating miR-1238 serves as a clinical biomarker and a promising therapeutic target for TMZ resistance in GBM. (PMID:30917935)
• Circular RNA circ_0005230 could directly sponge miR-1238 and miR-1299 to exert its oncogenic functions in cholangiocarcinoma. (PMID:30946694)
• Circ_0070934 promotes cell growth, migration and invasion and inhibits cell apoptosis in cutaneous squamous cell carcinoma. Circ_0070934 could sponge miR-1238 and miR-1247-5p. The oncogenic function of circular RNA circ_0070934 is attributed to its suppression of miR-1238 and miR-1247-5p. (PMID:30967263)
• CircRNA circ_0067772 aggravates the malignant progression of cutaneous squamous cell carcinoma by regulating miR-1238-3p/FOXG1 axis. (PMID:33709381)
• Circ_0057558 accelerates the development of prostate cancer through miR-1238-3p/SEPT2 axis. (PMID:36738516)
• circSKA3 promotes colorectal cancer metastases through miR-1238 and methylation. (PMID:37256443)
• Association between miR-202, miR-211, and miR-1238 gene polymorphisms and risk of vitiligo. (PMID:38597990)
• Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT. (PMID:38610009)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.