MIR124-1

Summary

MIR124-1 (microRNA 124-1, HGNC:31502) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406907 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31502
Approved symbol	MIR124-1
Name	microRNA 124-1
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-124a-1, hsa-mir-124-1
Ensembl gene	ENSG00000284321
Ensembl biotype	miRNA
OMIM	609327
Entrez	406907
RNAcentral	URS000075A939 — miRNA, 85 nt, 90 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385275

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385275 — 1 exons

Exon	Start	End
ENSE00001500281	9903388	9903472

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 69.12.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	69.12	gold quality
hypothalamus	UBERON:0001898	60.81	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	59.76	gold quality
nucleus accumbens	UBERON:0001882	58.10	gold quality
cerebellar hemisphere	UBERON:0002245	54.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• CEBPa is a target for MiR-124a in acute myeloid leukemia. (PMID:18451139)
• CDK6 is regulated by microRNA 124 in medulloblastoma and that miR 124 modulates medulloblastoma cell growth (PMID:18607543)
• The miR-124a-controlled downregulation of NFKBIZ protein is involved in the regulation of NF-kappaappa B activity. (PMID:19502795)
• miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. (PMID:19843643)
• these results demonstrate that by repressing the mineralocorticoid receptor gene NR3C2, miR-124 and miR-135a could participate in the regulation of renin-angiotensin-aldosterone system and thereby might be involved in blood pressure regulation. (PMID:19944075)
• transgerminal neuroectodermal conversion of hMSCs into NSC-like cells is accompanied by extensive changes of their global gene expression profile, which might be controlled in part by transcription factor networks related to HIF-1 and miR-124a (PMID:20599952)
• miR-124a may play an active role in inhibiting embryonic stem cell differentiation downregulating expression of SLUG and IQGAP1, thereby maintaining stemness. (PMID:20665740)
• MiR-124 is involved in the fine tuning of amyloid precursor protein (APP) regulation mRNA alternative splicing. (PMID:21062284)
• Data suggest disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression. (PMID:21112327)
• Lentiviral-expressing miR124 and let7d in the nucleus accumbens attenuates cocaine-induced conditioned place preference. (PMID:21307844)
• Hypermethylation of hsa-miR-124a is present in gastric cancer, and is associated with increased expression of CDK6 and Rb protein. (PMID:21365509)
• Findings suggest miR-124 plays a role in regulating cytoskeletal events and epithelial-mesenchymal cell transition, and inhibits the invasive and/or metastatic potential of hepatocellular carcinoma, probably by repressing ROCK2 and EZH2. (PMID:21672940)
• The hypermethylation of miRNA-34b/c and miRNA-124a gene promoters may play a crucial role in the occurrence and development of gastric carcinoma. (PMID:21914401)
• DNA methylation of miR-34a, -34b/c, -124-1 and -203 in Philadelphia-negative (Ph-ve) myeloproliferative neoplasms, was studied. (PMID:22082000)
• miR-124 suppresses multiple steps of metastasis by diverse mechanisms in breast cancer cells. (PMID:22085528)
• Identification and validation of three miRNAs (miR-124, miR-147 and miR-193a-3p) as novel tumor suppressors that co-target EGFR-driven cell-cycle network proteins and inhibit cell-cycle progression and proliferation in breast cancer. (PMID:22333974)
• In an association study of Mongolian Alzheimer’s disease (AD) patients and controls, neither genotype nor allele distribution difference for primary-miR-124 is found in AD patients compared with controls. (PMID:22430032)
• miR-124 inhibits cell proliferation in gastric cancer through down-regulation of SPHK1. (PMID:22450659)
• The expression of miR-124 in myelodysplastic syndrome patients is inhibited, which may be associated with the abnormal methylation of its promoter. (PMID:22541098)
• MiR-124 may play a certain role in the development of colorectal cancer. (PMID:22885837)
• these results demonstrate that miR-124 functions as a growth-suppressive miRNA and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA. (PMID:22940133)
• found that (i) miR-124 directly targets the androgen receptor (AR) and subsequently induces an upregulation of p53 (PMID:23069658)
• Induction of neuronal specific microRNAs mir-124 and mir-9 on umbilical cord blood cells indicates that the cells may be novel neurogenic differentiation CD133+/CD34+ stem cells. (PMID:23135476)
• Loss of miR-124 expression is associated with medulloblastoma. (PMID:23172372)
• we found that miR-124-1, miR-124-2 and miR-124-3 are highly methylated in pancreatic cancer tissues (PMID:23334332)
• Loss of miR-124 is associated with decreased radiosensitivity in glioma. (PMID:23761023)
• MiR-124 inhibits the growth of glioblastoma through the downregulation of SOS1. (PMID:23817964)
• miR-124 was down-regulated specifically in colon tissues from pediatric patients with ulcerative colitis and directly targeted STAT3 messenger RNA (PMID:23856509)
• These results revealed a novel mechanism that miR-124 inhibits glioma cells migration and invasion via ROCK1 downregulation. (PMID:23936026)
• The miR-124 modulates LPS-induced cytokine production by targeting signal transducer and activator of transcription 3 (STAT3) to decrease IL-6 production and TNF-alpha converting enzyme (TACE) to reduce TNF-alpha release. (PMID:23979021)
• positive interaction between REST activity and miR-124a using a luciferase-binding assay and we correlated the reciprocal expression of REST and miR-124a in our clinical cohort (PMID:24068568)
• findings suggest that miR-124-1 underexpression is a common event and might have a favorable impact on prognosis in AML (PMID:24135052)
• these findings show that miR-124 functions as tumor suppressor in hepatocellular carcinoma (HCC) by targeting STAT3, and miR-124 may therefore serve as a biomarker for diagnosis and therapeutics in HCC. (PMID:24211205)
• The methylation status of miR-124a seen in this study concurs with that reported in tumor cells, indicating epigenetic dysregulation constituents, a mechanism in the development of rheumatoid arthritis. (PMID:24223605)
• the antitumor effects of miR-124 are achieved, at least partly, through down regulation of STAT3 mRNA and its downstream target genes. (PMID:24287565)
• our study suggests that miR-124 serves as a regulator of the M2 polarization in various subsets of monocytic cells both in vitro and in vivo. (PMID:24358127)
• miR-124a-1, miR-124a-2, and miR-124a-3 genes are frequently methylated in breast cancer and play a role in tumor growth and aggressivity. (PMID:24375250)
• Finally, the functional roles of miR-155-5p and miR-124-3p whose expressions altered significantly between GSCs and NSCs were addressed (PMID:24519663)
• The brain-enriched miRNA-124a ia a novel marker for prediction of neurological outcome following cardiac arrest. (PMID:24588965)
• miR-124 and its target gene, SOX9, are overexpressed in the stenotic colon segment of patients with HSCR, and may have a significant role in the development of HSCR. (PMID:24604230)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir124a-1	ENSMUSG00000065597
rattus_norvegicus	Mir124-1	ENSRNOG00000035471

Paralogs (2): MIR124-3 (ENSG00000207598), MIR124-2 (ENSG00000207816)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.