MIR124-1HG

Summary

MIR124-1HG (MIR124-1 host gene, HGNC:27231) is a long non-coding RNA gene on chromosome 8p23.1.

Predicted to act upstream of or within several processes, including long-term synaptic potentiation; miRNA-mediated post-transcriptional gene silencing; and sensory perception of sound. Predicted to be part of RISC complex.

Source: NCBI Gene 157627 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27231
Approved symbol	MIR124-1HG
Name	MIR124-1 host gene
Location	8p23.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	Rncr3, neuroLNC
Ensembl gene	ENSG00000253230
Ensembl biotype	lncRNA
Entrez	157627
RNAcentral	URS000075B2F4 — lncRNA, 2942 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 49 — 49 lncRNA

ENST00000517675, ENST00000518557, ENST00000519461, ENST00000521242, ENST00000521863, ENST00000653424, ENST00000654192, ENST00000656078, ENST00000661494, ENST00000662006, ENST00000665174, ENST00000666267, ENST00000667251, ENST00000667273, ENST00000669913, ENST00000685227, ENST00000689122, ENST00000693340, ENST00000693527, ENST00000700799, ENST00000700864, ENST00000701445, ENST00000701455, ENST00000701497, ENST00000701855, ENST00000701915, ENST00000702057, ENST00000702101, ENST00000843868, ENST00000843869, ENST00000843870, ENST00000843871, ENST00000843872, ENST00000843873, ENST00000843874, ENST00000843875, ENST00000843876, ENST00000843877, ENST00000843878, ENST00000843879, ENST00000843880, ENST00000843881, ENST00000843882, ENST00000843883, ENST00000843884, ENST00000843885, ENST00000843886, ENST00000843887, ENST00000843888

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000517675 — 1 exons

Exon	Start	End
ENSE00004270187	9899744	9903397

Expression profiles

Bgee: expression breadth ubiquitous, 109 present calls, max score 99.81.

FANTOM5 (CAGE): breadth broad, TPM avg 12.7521 / max 1858.6668, expressed in 304 samples.

FANTOM5 promoters (18 alternative TSS)

Promoter ID	TPM avg	Samples expressed
91774	3.3165	254
91783	3.0888	212
91781	3.0163	186
91782	0.9811	135
91790	0.7693	154
91780	0.3377	85
91772	0.2428	72
91776	0.2206	81
91779	0.1520	71
91778	0.1420	71

Top tissues by expression

109 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar cortex	UBERON:0002129	99.81	gold quality
cerebellar hemisphere	UBERON:0002245	99.81	gold quality
cerebellum	UBERON:0002037	99.80	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.79	gold quality
primary visual cortex	UBERON:0002436	99.06	gold quality
superior frontal gyrus	UBERON:0002661	97.70	gold quality
right frontal lobe	UBERON:0002810	97.52	gold quality
cortical plate	UBERON:0005343	96.87	gold quality
Brodmann (1909) area 9	UBERON:0013540	96.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	96.33	gold quality
anterior cingulate cortex	UBERON:0009835	95.34	gold quality
Ammon’s horn	UBERON:0001954	94.84	gold quality
ganglionic eminence	UBERON:0004023	93.84	gold quality
amygdala	UBERON:0001876	93.78	gold quality
temporal lobe	UBERON:0001871	93.72	gold quality
nucleus accumbens	UBERON:0001882	93.59	gold quality
putamen	UBERON:0001874	93.52	gold quality
cerebral cortex	UBERON:0000956	93.48	gold quality
caudate nucleus	UBERON:0001873	93.26	gold quality
hypothalamus	UBERON:0001898	92.55	gold quality
brain	UBERON:0000955	90.89	gold quality
frontal cortex	UBERON:0001870	90.67	gold quality
substantia nigra	UBERON:0002038	90.38	gold quality
prefrontal cortex	UBERON:0000451	85.35	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.88	gold quality
ventricular zone	UBERON:0003053	74.57	gold quality
corpus callosum	UBERON:0002336	73.79	gold quality
placenta	UBERON:0001987	71.05	gold quality
bone marrow cell	CL:0002092	64.54	silver quality
blood	UBERON:0000178	62.15	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	40.04
E-ANND-3	no	2.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• RNCR3 has an atheroprotective role in atherosclerosis. (PMID:27253412)
• Long Non-coding RNA LINC-PINT and LINC00599 Polymorphisms are Associated With High-altitude Pulmonary Edema in Chinese. (PMID:31761491)
• Association between LINC-PINT and LINC00599 gene polymorphism and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China. (PMID:34245766)
• LINC00599 influences smoke-related chronic obstructive pulmonary disease and regulates CSE-induced epithelial cell apoptosis and inflammation by targeting miR-212-5p/BASP1 axis. (PMID:36541900)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.