MIR124-2

Summary

MIR124-2 (microRNA 124-2, HGNC:31503) is a microRNA gene on chromosome 8q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406908 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31503
Approved symbol	MIR124-2
Name	microRNA 124-2
Location	8q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-124a-2, hsa-mir-124-2
Ensembl gene	ENSG00000207816
Ensembl biotype	miRNA
Entrez	406908
RNAcentral	URS000023AB58 — miRNA, 109 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385081

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385081 — 1 exons

Exon	Start	End
ENSE00001500087	64379149	64379257

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 81.98.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	81.98	gold quality
lung	UBERON:0002048	80.88	gold quality
transverse colon	UBERON:0001157	68.24	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.94	gold quality
ectocervix	UBERON:0012249	67.83	gold quality
tibial nerve	UBERON:0001323	67.52	gold quality
Ammon’s horn	UBERON:0001954	66.95	gold quality
caudate nucleus	UBERON:0001873	65.96	gold quality
putamen	UBERON:0001874	64.94	gold quality
anterior cingulate cortex	UBERON:0009835	64.78	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.37	gold quality
cerebral cortex	UBERON:0000956	64.12	gold quality
cerebellar hemisphere	UBERON:0002245	63.96	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.47	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.16	gold quality
frontal cortex	UBERON:0001870	61.18	gold quality
spleen	UBERON:0002106	60.78	gold quality
right frontal lobe	UBERON:0002810	60.54	gold quality
nucleus accumbens	UBERON:0001882	59.63	gold quality
corpus callosum	UBERON:0002336	55.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. (PMID:19843643)
• Data suggest disruption of miR-124-mediated repression of ITGB1 may be a key factor in OSCC progression. (PMID:21112327)
• The methylation of mir-9-3, mir-124-2, and mir-124-3 was individually associated with an advanced T factor independent of age, sex, and smoking habit. (PMID:21917081)
• Data indicate that DNA methylation status of multiple genes CADM1, MAL and hsa-miR-124-2 was analyzed in human papillomavirus (hrHPV)-positive cervical scrape. (PMID:23176198)
• we found that miR-124-1, miR-124-2 and miR-124-3 are highly methylated in pancreatic cancer tissues (PMID:23334332)
• miR-124a-1, miR-124a-2, and miR-124a-3 genes are frequently methylated in breast cancer and play a role in tumor growth and aggressivity. (PMID:24375250)
• miR-124 and its target gene, SOX9, are overexpressed in the stenotic colon segment of patients with HSCR, and may have a significant role in the development of HSCR. (PMID:24604230)
• miR-124-3p and miR-16 are diagnostic markers to discriminate hemorrhagic and ischemic stroke (PMID:24650689)
• Findings identify that KITENIN-targeting miR-124, miR-27a, and miR-30b function as endogenous inhibitors of colorectal cancer cell motility and demonstrate that miR-124 plays a suppressor role in colorectal tumorigenesis. (PMID:24909917)
• MIRN124 binds to the 3’UTR of iASPP and suppressing mRNA expression and the proliferation of prostate tumor cells. (PMID:24966937)
• Findings suggest that miR-124 inhibits TGF-alpha-induced epithelial-mesenchymal transition in human prostate cancer cell line DU145 by targeting Slug. (PMID:24969691)
• A negative regulatory role of miR-124 in fine-tuning inflammatory response in alveolar macrophages upon mycobacterial infection, in part through a mechanism by directly targeting TLR signaling. (PMID:24995397)
• Results demonstrate that miR-124 functions as a tumor-suppressive microRNA in nasopharyngeal carcinoma by repressing Foxq1 expression. (PMID:25098939)
• miR-124 binds AmotL1 3’UTR and down-regulates its expression repressing vasculogenic mimicry and cell motility in cervical cancer cells (PMID:25218344)
• DNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer (PMID:25281766)
• Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8. (PMID:25400731)
• Data indicate differential expression of microRNAs miR-124 and let-7a between the smoking and control groups. (PMID:25598229)
• Suggest that miR-124 acts as a tumor-suppressor and a modulator of energy metabolism through a PTB1/PKM1/PKM2 feedback cascade in human colorectal tumor cells. (PMID:25818238)
• found a negative feedback loop between androgen receptor and miR-124 expression in prostate cancer cells (PMID:25860954)
• Decreased expression of miR-124 might be associated with tumor progression and poor prognosis in patients with breast cancer. (PMID:25924779)
• miR-124 regulates Tip110 expression and differentiation of human cord blood CD34(+) cells and suggests important roles of miR-124/Tip110 in hematopoiesis (PMID:25928721)
• miR-124 promotes hyperplasia and contributes to invasion of colorectal cancer cells, but downregulates ROCK1. (PMID:25987767)
• Paeoniflorin inhibits cell viability and induces apoptosis through the up-regulation of miR-124 and suppression of PI3K/Akt and STAT3 signaling in gastric carcinoma cells. (PMID:26109806)
• Overexpression of miR-124 decreased ESX and EGFR levels in head and neck squamous cell carcinoma cells and reduced cell invasion, migration, proliferation, and colony formation. (PMID:26227488)
• miR-124 could control the fate of target gene UHRF1 mRNA by binding 3’-UTR (PMID:26310391)
• The use of CADM1, MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus. (PMID:26473640)
• miR-124 and miR-506 inhibit progression and increase sensitivity to chemotherapy by targeting DNMT3B and DNMT1 in colorectal carcinoma. (PMID:26497367)
• meta-analysis suggests that the miR-124 rs531564 C > G polymorphism is an important risk factor for cancers among the Chinese population (PMID:26625819)
• MiR-124 is an important miRNA modulating neurogenic transdifferentiation of ADMSCs at least partly via the miR-124/RhoA/ROCK1 signaling pathway. (PMID:26745800)
• data show a novel feedback loop between miR-124 and transforming growth factor-beta (TGF-beta) pathway driving non-small cell lung cancer (NSCLC) metastasis, which might provide a new insight into treatment of NSCLC progression (PMID:26818357)
• FAM19A4/mir124-2 methylation analysis performs equally well in HPV-positive lavage- and brush self-samples to identify women with CIN3+. In combination with HPV16/18 genotyping, significantly higher CIN3+ sensitivities are obtained, at decreased specificity. (PMID:26921784)
• miR-124 functions as a tumor suppressor in lung adenocarcinoma by directly targeting SOX9. (PMID:26935152)
• miR-124 inhibits lung cancer cell migration and invasion through suppressing epithelial-mesenchymal transition (EMT) and inducing apoptosis of the lung cancer cells. (PMID:27251409)
• The introduction of miR-214 significantly promoted the proliferation of pulmonary artery smooth muscle cells by suppressing cell apoptosis, and this effect was mediated by the downregulation of cyclin L2. (PMID:27381447)
• miR124 prevents tendon differentiation via suppressing egr1 expression. (PMID:27569005)
• Its upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1 (PMID:27743351)
• miR-124 expression is decreased in breast cancer and plays an important role as a tumor suppressor gene by targeting SNAI2. (PMID:27748910)
• Serum microRNA miR-124 levels may function as diagnostic biomarkers in patients with pancreatic ductal adenocarcinoma (PDAC), and may have prognostic impact in patients with PDAC. (PMID:27922430)
• Hypermethylation-mediated suppression of miR-124 might be involved in tumor initiation and metastasis by suppressing the mesenchymal features of Ewing sarcoma cells. (PMID:28055964)
• Results indicate that microRNA miR-124 inhibited glioblastoma growth and potentiated chemosensitivity by targeting Aurora kinase A (AURKA), which may represent promising targets and rational therapeutic options for glioblastoma. (PMID:28242198)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir124-2	ENSDARG00000081311
danio_rerio	mir124-3	ENSDARG00000081423
mus_musculus	Mir124a-2	ENSMUSG00000093073
rattus_norvegicus	Mir124-2	ENSRNOG00000035499

Paralogs (2): MIR124-3 (ENSG00000207598), MIR124-1 (ENSG00000284321)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.