MIR124-2HG

Summary

MIR124-2HG (MIR124-2 host gene, HGNC:48723) is a long non-coding RNA gene on chromosome 8q12.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48723
Approved symbol	MIR124-2HG
Name	MIR124-2 host gene
Location	8q12.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000254377
Ensembl biotype	lncRNA
Entrez	100130155
RNAcentral	URS000075C768 — lncRNA, 6557 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 40 — 40 lncRNA

ENST00000519741, ENST00000520799, ENST00000521441, ENST00000524060, ENST00000524284, ENST00000657723, ENST00000658332, ENST00000663091, ENST00000665390, ENST00000671254, ENST00000671640, ENST00000685732, ENST00000686827, ENST00000688418, ENST00000688752, ENST00000689669, ENST00000690865, ENST00000701873, ENST00000702036, ENST00000702091, ENST00000772496, ENST00000772497, ENST00000772498, ENST00000772499, ENST00000772500, ENST00000772501, ENST00000772502, ENST00000772503, ENST00000772504, ENST00000772505, ENST00000772506, ENST00000772507, ENST00000772508, ENST00000772509, ENST00000772510, ENST00000772511, ENST00000772512, ENST00000772513, ENST00000772514, ENST00000772515

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000519741 — 2 exons

Exon	Start	End
ENSE00002130133	64377960	64378489
ENSE00002136458	64381603	64383286

Expression profiles

Bgee: expression breadth broad, 88 present calls, max score 97.02.

FANTOM5 (CAGE): breadth broad, TPM avg 5.4978 / max 419.2166, expressed in 229 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
89122	2.9727	208
89129	0.6162	103
89127	0.4548	124
89123	0.3584	136
89120	0.3454	134
89124	0.2946	82
89121	0.2564	108
89126	0.0728	40
89125	0.0592	25
89128	0.0317	14

Top tissues by expression

197 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 23	UBERON:0013554	97.02	gold quality
primary visual cortex	UBERON:0002436	96.54	gold quality
middle temporal gyrus	UBERON:0002771	95.67	gold quality
cortical plate	UBERON:0005343	94.98	gold quality
occipital lobe	UBERON:0002021	94.84	gold quality
ganglionic eminence	UBERON:0004023	91.93	gold quality
postcentral gyrus	UBERON:0002581	91.69	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.68	gold quality
superior frontal gyrus	UBERON:0002661	91.51	gold quality
right frontal lobe	UBERON:0002810	91.43	gold quality
parietal lobe	UBERON:0001872	90.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	90.45	gold quality
neocortex	UBERON:0001950	88.27	gold quality
frontal cortex	UBERON:0001870	87.96	gold quality
anterior cingulate cortex	UBERON:0009835	87.91	gold quality
endothelial cell	CL:0000115	87.03	silver quality
cerebral cortex	UBERON:0000956	86.69	gold quality
Brodmann (1909) area 46	UBERON:0006483	85.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.99	gold quality
prefrontal cortex	UBERON:0000451	84.74	gold quality
cerebellar hemisphere	UBERON:0002245	84.15	gold quality
cerebellar vermis	UBERON:0004720	84.06	gold quality
cerebellar cortex	UBERON:0002129	83.95	gold quality
cerebellum	UBERON:0002037	82.84	gold quality
forebrain	UBERON:0001890	82.49	gold quality
lateral nuclear group of thalamus	UBERON:0002736	82.15	gold quality
brain	UBERON:0000955	82.07	gold quality
entorhinal cortex	UBERON:0002728	81.47	gold quality
temporal lobe	UBERON:0001871	81.34	gold quality
putamen	UBERON:0001874	81.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• We found that miR-124 directly downregulates the levels of AR transcript variants, as well as enhancer of Zeste homolog 2 (EZH2) and Src tyrosine kinase (Src). (PMID:26573802)
• data show a novel feedback loop between miR-124 and transforming growth factor-beta (TGF-beta) pathway driving non-small cell lung cancer (NSCLC) metastasis, which might provide a new insight into treatment of NSCLC progression (PMID:26818357)
• miR-124 inhibits lung cancer cell migration and invasion through suppressing epithelial-mesenchymal transition (EMT) and inducing apoptosis of the lung cancer cells. (PMID:27251409)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.