MIR1243

Summary

MIR1243 (microRNA 1243, HGNC:35304) is a microRNA gene on chromosome 4q25.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302188 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35304
Approved symbol	MIR1243
Name	microRNA 1243
Location	4q25
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1243
Ensembl gene	ENSG00000283193
Ensembl biotype	miRNA
Entrez	100302188
RNAcentral	URS000075E486 — ncRNA, 93 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636083

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636083 — 1 exons

Exon	Start	End
ENSE00003797855	113106863	113106955

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 88.18.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	88.18	gold quality
stomach	UBERON:0000945	77.77	gold quality
calcaneal tendon	UBERON:0003701	77.72	gold quality
adrenal tissue	UBERON:0018303	77.34	gold quality
intestine	UBERON:0000160	75.67	gold quality
heart	UBERON:0000948	75.06	gold quality
adult mammalian kidney	UBERON:0000082	73.03	gold quality
gastrocnemius	UBERON:0001388	72.54	gold quality
colon	UBERON:0001155	71.05	gold quality
lung	UBERON:0002048	70.16	gold quality
tibial artery	UBERON:0007610	69.34	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.30	gold quality
left coronary artery	UBERON:0001626	69.26	gold quality
left adrenal gland	UBERON:0001234	68.99	gold quality
heart left ventricle	UBERON:0002084	68.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.80	gold quality
granulocyte	CL:0000094	68.70	gold quality
thoracic mammary gland	UBERON:0005200	67.80	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.71	gold quality
caudate nucleus	UBERON:0001873	67.47	gold quality
substantia nigra	UBERON:0002038	67.27	gold quality
transverse colon	UBERON:0001157	67.24	gold quality
minor salivary gland	UBERON:0001830	67.12	gold quality
right atrium auricular region	UBERON:0006631	67.01	gold quality
Ammon’s horn	UBERON:0001954	66.64	gold quality
vagina	UBERON:0000996	66.55	gold quality
skin of abdomen	UBERON:0001416	66.55	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.10	gold quality
adenohypophysis	UBERON:0002196	65.45	gold quality
ascending aorta	UBERON:0001496	65.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-509-5p was associated with worse overall survival in patients with pancreatic cancer and was identified as an independently selected predictor of mortality. Our findings suggest that miR-509-5p and miR-1243 might be novel chemotherapeutic targets and serve as biomarkers in pancreatic cancer. . (PMID:28638102)
• Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis. (PMID:34257535)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.