MIR1244-1

Summary

MIR1244-1 (microRNA 1244-1, HGNC:35310) is a microRNA gene on chromosome 2q37.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302285 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35310
Approved symbol	MIR1244-1
Name	microRNA 1244-1
Location	2q37.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1244
Ensembl gene	ENSG00000284378
Ensembl biotype	miRNA
Entrez	100302285
RNAcentral	URS000075BB1F — miRNA, 85 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612829

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612829 — 1 exons

Exon	Start	End
ENSE00003743779	231713314	231713398

Expression profiles

Bgee: expression breadth tissue_specific, 2 present calls, max score 97.73.

Top tissues by expression

2 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
dorsolateral prefrontal cortex	UBERON:0009834	97.73	gold quality
blood	UBERON:0000178	89.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• In summary, we found that miR-1244 affected cisplatin-treated non-small cell lung cancer via MEF2D expression. (PMID:28498474)
• MiR-1244 directly targets MDM2 in osteosarcoma. (PMID:31200957)
• study shows that LINC00504 promotes Ovarian cancer (OC) cell progression and stimulates aerobic glycolysis by interacting with miR-1244, which indicates that LINC00504 might act as a promising therapeutic target for OC treatment. (PMID:31691157)
• Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244/ROCK1 axis in ovarian cancer. (PMID:33737494)
• Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis. (PMID:36109749)
• RBM4 regulates cellular senescence via miR1244/SERPINE1 axis. (PMID:36639375)

Cross-species orthologs

0 orthologs

Paralogs (3): MIR1244-3 (ENSG00000283429), MIR1244-4 (ENSG00000283475), MIR1244-2 (ENSG00000283498)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.