MIR1245A

Summary

MIR1245A (microRNA 1245a, HGNC:35311) is a microRNA gene on chromosome 2q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302219 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35311
Approved symbol	MIR1245A
Name	microRNA 1245a
Location	2q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1245
Ensembl gene	ENSG00000221502
Ensembl biotype	miRNA
Entrez	100302219
RNAcentral	URS000075F01A — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408575

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408575 — 1 exons

Exon	Start	End
ENSE00001565210	188978092	188978161

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 95.74.

Top tissues by expression

219 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of hip	UBERON:0001554	95.74	gold quality
vena cava	UBERON:0004087	94.05	gold quality
parietal pleura	UBERON:0002400	93.38	gold quality
adrenal tissue	UBERON:0018303	93.24	gold quality
visceral pleura	UBERON:0002401	92.73	gold quality
upper arm skin	UBERON:0004263	92.69	gold quality
layer of synovial tissue	UBERON:0007616	92.51	gold quality
calcaneal tendon	UBERON:0003701	92.19	gold quality
mammalian vulva	UBERON:0000997	90.43	gold quality
pericardium	UBERON:0002407	90.25	gold quality
urinary bladder	UBERON:0001255	88.71	gold quality
caecum	UBERON:0001153	88.01	gold quality
synovial joint	UBERON:0002217	87.86	gold quality
cartilage tissue	UBERON:0002418	87.53	gold quality
germinal epithelium of ovary	UBERON:0001304	86.92	gold quality
pylorus	UBERON:0001166	85.16	gold quality
tendon	UBERON:0000043	84.91	gold quality
vermiform appendix	UBERON:0001154	84.67	gold quality
myometrium	UBERON:0001296	84.20	gold quality
saphenous vein	UBERON:0007318	84.09	gold quality
endometrium	UBERON:0001295	83.16	gold quality
adipose tissue	UBERON:0001013	82.99	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.25	gold quality
cardiac muscle of right atrium	UBERON:0003379	82.19	silver quality
seminal vesicle	UBERON:0000998	82.08	gold quality
urethra	UBERON:0000057	82.06	gold quality
penis	UBERON:0000989	82.04	gold quality
uterus	UBERON:0000995	81.99	gold quality
fundus of stomach	UBERON:0001160	81.55	gold quality
buccal mucosa cell	CL:0002336	81.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.19

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• C-myc up-regulated miR-1245 expression which led to down-regulation of BRCA2. (PMID:22158906)
• High microRNA-1245 expression is associated with non-Hodgkin’s lymphoma, acute myelogenous leukemia and myelodysplastic syndrome. (PMID:22491735)
• Hsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer. (PMID:35081869)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.