MIR1245B

Summary

MIR1245B (microRNA 1245b, HGNC:41794) is a microRNA gene on chromosome 2q32.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616324 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41794
Approved symbol	MIR1245B
Name	microRNA 1245b
Location	2q32.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1245b
Ensembl gene	ENSG00000283238
Ensembl biotype	miRNA
Entrez	100616324
RNAcentral	URS000075AA79 — miRNA, 69 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636115

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636115 — 1 exons

Exon	Start	End
ENSE00003800945	188978093	188978161

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 81.07.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	81.07	gold quality
placenta	UBERON:0001987	79.32	gold quality
calcaneal tendon	UBERON:0003701	79.02	gold quality
gall bladder	UBERON:0002110	76.73	gold quality
endometrium	UBERON:0001295	75.19	gold quality
blood	UBERON:0000178	74.16	gold quality
fundus of stomach	UBERON:0001160	73.18	gold quality
lymph node	UBERON:0000029	71.79	gold quality
urinary bladder	UBERON:0001255	71.47	gold quality
myometrium	UBERON:0001296	71.42	gold quality
gastrocnemius	UBERON:0001388	71.34	gold quality
tibial artery	UBERON:0007610	70.76	gold quality
ascending aorta	UBERON:0001496	70.61	gold quality
thoracic aorta	UBERON:0001515	70.56	gold quality
descending thoracic aorta	UBERON:0002345	70.44	gold quality
stomach	UBERON:0000945	70.23	gold quality
body of stomach	UBERON:0001161	69.88	gold quality
rectum	UBERON:0001052	69.77	gold quality
heart left ventricle	UBERON:0002084	69.72	gold quality
right atrium auricular region	UBERON:0006631	69.21	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.08	gold quality
lower esophagus	UBERON:0013473	68.07	gold quality
omental fat pad	UBERON:0010414	68.00	gold quality
Ammon’s horn	UBERON:0001954	67.96	gold quality
adipose tissue	UBERON:0001013	67.64	gold quality
right ovary	UBERON:0002118	67.60	gold quality
left adrenal gland	UBERON:0001234	67.48	gold quality
left coronary artery	UBERON:0001626	67.31	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.14	gold quality
transverse colon	UBERON:0001157	67.09	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long non-coding RNA HCG11 enhances osteosarcoma phenotypes by sponging miR-1245b-5p that directly inhibits plakophilin 2. (PMID:34949159)
• Deregulation of miR-1245b-5p and miR-92a-3p and their potential target gene, GATA3, in epithelial-mesenchymal transition pathway in breast cancer. (PMID:38173189)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.