MIR1246

Summary

MIR1246 (microRNA 1246, HGNC:35312) is a microRNA gene on chromosome 2q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302142 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35312
Approved symbol	MIR1246
Name	microRNA 1246
Location	2q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1246
Ensembl gene	ENSG00000283203
Ensembl biotype	miRNA
Entrez	100302142
RNAcentral	URS000075AC0B — miRNA, 73 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636535

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636535 — 1 exons

Exon	Start	End
ENSE00003799758	176600980	176601052

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 74.98.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	74.98	gold quality
gastrocnemius	UBERON:0001388	73.42	gold quality
endometrium	UBERON:0001295	72.04	gold quality
tibial artery	UBERON:0007610	71.56	gold quality
left adrenal gland cortex	UBERON:0035825	69.80	gold quality
body of pancreas	UBERON:0001150	69.73	gold quality
right atrium auricular region	UBERON:0006631	68.67	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.30	gold quality
ascending aorta	UBERON:0001496	66.94	gold quality
body of stomach	UBERON:0001161	66.58	gold quality
fundus of stomach	UBERON:0001160	66.30	gold quality
thoracic mammary gland	UBERON:0005200	65.98	gold quality
esophagus mucosa	UBERON:0002469	65.59	gold quality
minor salivary gland	UBERON:0001830	64.75	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.28	gold quality
spleen	UBERON:0002106	64.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.15	gold quality
skin of leg	UBERON:0001511	63.87	gold quality
zone of skin	UBERON:0000014	63.55	gold quality
stomach	UBERON:0000945	63.44	gold quality
left uterine tube	UBERON:0001303	62.06	gold quality
vagina	UBERON:0000996	61.98	gold quality
left ovary	UBERON:0002119	61.67	gold quality
skin of abdomen	UBERON:0001416	60.65	gold quality
tibial nerve	UBERON:0001323	59.73	gold quality
left testis	UBERON:0004533	48.72	gold quality
colon	UBERON:0001155	46.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• The miR-1246 as a novel target of p53 and its analogs p63 and p73 to suppress the expression of DYRK1A and consequently activate NFAT, both of which are associated with Down syndrome and possibly with tumorigenesis (PMID:22751441)
• miR-1246 might play a role in neurological pathogenesis of human enterovirus 71 by regulating DLG3 gene in infected cells. (PMID:24739954)
• MiR-1246 induced cervical cancer SiHa cell proliferation, invasion and migration and Preliminary evidence suggests that it might promote CSCC tumorigenesis and progression by the suppression of its target gene THBS2. (PMID:24806621)
• miR-1246 promotes UVB-induced apoptosis by downregulating RTKN2 expression and that UVB-upregulated miR-1246 released RTKN2-dependent resistance to UVB-induced apoptosis by targeting RTKN2 post-transcriptionally in keratinocyte cells. (PMID:24880483)
• miR-1246 expression was associated with chemoresistance and CSC-like properties via CCNG2, and could predict worse prognosis in pancreatic cancer patients (PMID:25117811)
• Study showed that miR-1246 is highly expressed in hepatocellular carcinoma cells, and down-regulates CADM1 enhancing migration and invasion . (PMID:25159494)
• the mi-RNAs hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells following expression of EBOV GP (PMID:25218824)
• colorectal cancer cell-derived microvesicles containing mir1246 promote angiogenesis. (PMID:25218966)
• Overexpression of miR-1246 in the sera is associated with active forms of inflammatory bowel disease. (PMID:25628040)
• High miR-1246 expression is associated with poor prognosis in oral squamous cell carcinoma. (PMID:25791131)
• Results show that mir1246 is the most abundant miRNA in human sperm and its CpG-island promoter is packaged in chromatin with active histone marks suggesting an epigenetic regulation. (PMID:25904136)
• Real-time quantitative polymerase chain reaction technology was used to detect the expression of miR-1246 in 68 cervical cancer tissues and 52 normal tissues. (PMID:26074491)
• An miR-1246 target site in the noncoding region of F8 mRNA is able to confirm the suppressory role of hsa-miR-1246 on F8 expression in a stable lymphoblastoid cell line expressing FVIII. (PMID:26176629)
• Upregulation of miR1246 mediated the malignant progression of colorectal cancer and is partly attributed to the downregulation of the expression of CycG2. (PMID:26573378)
• Anti-miR-1246 and anti-miR-1290 suppressed proliferation, sphere-formation, colony formation and invasion of NSCLC. CSCs-associated miR-1246, or miR-1290 may be important in the invasion or metastasis of NSCLC. (PMID:26711929)
• Data suggest that the early-phase circulating miR-1246 is an indicator of hepatic injury and a prognostic biomarker for tumor recurrence and survival of HCC recipients after liver transplantation. (PMID:26918346)
• The oncogene-like extracellular miR-1246 could act as a signaling messenger between irradiated and non-irradiated lung cancer cells, more importantly, it contributes to cell radioresistance by directly suppressing the DR5 gene. (PMID:27129166)
• Tumor-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression. (PMID:27325363)
• Our findings uncover the noncanonical regulation of Wnt/beta-catenin in liver cancer stem cells by the Oct4/miR-1246 signaling axis, and also provide a novel diagnostic marker as well as therapeutic intervention for hepatocellular carcinoma (PMID:27639189)
• miR-1246 increased cell motility by directly targeting DENN/MADD Domain Containing 2D (DENND2D). Taken together, our findings support the metastatic role of exosomes and exosomal miRNAs, which highlights their potential for applications in miRNA-based therapeutics (PMID:27929118)
• Exosomal miRs 21, 23a, 92a and 1246 are overexpressed in colorectal cancer, and thus have the potential to be used as serum biomarkers for early detection. Simulations of the model show a relationship between the growth of the tumor diameter and the total mass of these miRs under some of the common mutations which occur in CRC. (PMID:27993628)
• Upregulation of MicroRNA-1246 Is Associated with BRAF Inhibitor Resistance in Melanoma Cells with Mutant BRAF (PMID:28052651)
• miR-1246 acts as both key-enhancer of pro-inflammatory responses in MSCs and putative oncomiR in breast cancer, suggesting its influence on cancer-related inflammation and breast cancer progression. (PMID:28159925)
• Authors discovered that increased expression of PB miRNA-720 and miRNA-1246 were associated with shorter progression-free survival, indicating poor prognosis. Study demonstrated that PB miRNA-720 and miRNA-1246 might act as a promoting factor in the development of MM and could be a diagnostic factor. (PMID:28601493)
• miR-1246 directly targets CCNG2 expression by binding to its 3’ Untranslated Regions and promotes exosome-enhanced cell proliferation, migration and chemotherapy resistance. (PMID:29216623)
• The authors’ analyses suggest exosomal miR-1246 as a promising prostate cancer biomarker with diagnostic potential that can predict disease aggressiveness. The data suggest that miR-1246 is a prostate cancer tumor suppressor miRNA that plays a pleiotropic role by inhibiting Epithelial-Mesenchymal Transition, cellular proliferation, survival, and promoting apoptosis. (PMID:29437039)
• Mutant p53 reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 in colon cancer. (PMID:29472616)
• miR-1246, which is markedly induced during human syncytiotrophoblast differentiation, targets GSK3beta and AXIN2, inhibitors of WNT/beta-catenin signaling, which is crucial for placental development. miR-1246 was significantly decreased in placentas of women with severe preeclampsia. (PMID:29546425)
• MiR-1246 was increased in exosomes secreted from 2 Gy-irradiated BEP2D cells and inhibited the proliferation of non-irradiated cells. Further data provide evidence that miR-1246 could function as a player packaged by exosomes, and that is transferred from targeted to nontargeted cells to contribute to radiation-induced bystander DNA damage. (PMID:30038324)
• microRNA-1246 (miR-1246) in human plasma exosomes is a breast cancer biomarker with nucleic acid functionalized Au nanoflare probe (PMID:30350935)
• VEGF stimulation promoted cell proliferation and migration of HUVECs mainly through regulating MIAT/miR-1246/ACE. (PMID:30782069)
• miR-1246 is highly enriched in exosomes derived from human cancer cells and that it originates from RNU2-1, a small nuclear RNA. (PMID:30806147)
• Results identified MIR1246 to be aberrantly expressed in the serum of lung cancer patients. MiR-1246 significantly increased the migration and invasion capabilities of cancer cell line promoting the epithelial-mesenchymal transition process. (PMID:30913872)
• MiR-1246 is not only critical to the maintenance of oral stemness but also important to the activation of myofibroblasts in oral submucosa fibrosis. (PMID:30928188)
• miR-1246 is involved in the anti-cancer effects of curcumin and irradiation through targeting the inhibition of p53 gene translation in bladder cancer cells (PMID:31236854)
• miR-1246 expression, Th17/Treg-related genes, and gp130-signal transducer and activator of transcription 3 (STAT3) pathway were detected by quantitative real-time polymerase chain reaction and western blotting (PMID:31433911)
• miR-1246 mediated H-GDE-induced M2 macrophage polarization by targeting TERF2IP to activate the STAT3 signaling pathway and inhibit the NF-kappaB signaling pathway (PMID:31485019)
• In cells of chondrogenic cell line CHON-001, CAIF overexpression mediated the inhibited expression of miR-1246 and secretion of IL-6, while miR-1246 overexpression reduced the effects of CAIF overexpression on IL-6 secretion. (PMID:31653823)
• Exosomes derived from human umbilical cord blood mesenchymal stem cells improve hepatic ischemia reperfusion injury via delivering miR-1246. (PMID:31709894)
• Radiogenomics predicts the expression of microRNA-1246 in the serum of esophageal cancer patients. (PMID:32054931)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.