MIR1247

Summary

MIR1247 (microRNA 1247, HGNC:35313) is a microRNA gene on chromosome 14q32.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302145 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35313
Approved symbol	MIR1247
Name	microRNA 1247
Location	14q32.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1247
Ensembl gene	ENSG00000283857
Ensembl biotype	miRNA
Entrez	100302145
RNAcentral	URS000075C329 — ncRNA, 136 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408206

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408206 — 1 exons

Exon	Start	End
ENSE00001564841	101560287	101560422

Expression profiles

Bgee: expression breadth broad, 39 present calls, max score 74.27.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2626 / max 57.7446, expressed in 350 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
144962	1.2626	350

Top tissues by expression

39 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	74.27	gold quality
tibial artery	UBERON:0007610	73.21	gold quality
caudate nucleus	UBERON:0001873	72.14	gold quality
lymph node	UBERON:0000029	71.87	gold quality
adipose tissue	UBERON:0001013	70.09	gold quality
skeletal muscle tissue	UBERON:0001134	69.68	gold quality
pancreas	UBERON:0001264	69.48	gold quality
stomach	UBERON:0000945	68.47	gold quality
heart left ventricle	UBERON:0002084	68.41	gold quality
muscle of leg	UBERON:0001383	65.77	gold quality
blood	UBERON:0000178	65.23	gold quality
adult mammalian kidney	UBERON:0000082	64.91	gold quality
putamen	UBERON:0001874	64.41	gold quality
esophagus mucosa	UBERON:0002469	63.87	gold quality
body of pancreas	UBERON:0001150	63.70	gold quality
skin of abdomen	UBERON:0001416	62.23	gold quality
right atrium auricular region	UBERON:0006631	60.70	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.68	gold quality
right frontal lobe	UBERON:0002810	59.43	gold quality
gastrocnemius	UBERON:0001388	59.34	gold quality
skin of leg	UBERON:0001511	59.08	gold quality
Ammon’s horn	UBERON:0001954	58.85	gold quality
hypothalamus	UBERON:0001898	58.79	gold quality
ascending aorta	UBERON:0001496	58.62	gold quality
anterior cingulate cortex	UBERON:0009835	58.50	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.47	gold quality
amygdala	UBERON:0001876	58.39	gold quality
vermiform appendix	UBERON:0001154	58.32	gold quality
prostate gland	UBERON:0002367	57.32	gold quality
lung	UBERON:0002048	56.98	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 21)

• depletion of SOX9 in chondrocytes resulted in increased levels of the mature, processed microRNA, suggesting a negative feedback loop between miR-1247 and its target SOX9. (PMID:24014021)
• MIR941 and MIR1247 are transcriptionally regulated by DNA methylation in gastric cancer and that they have tumor suppressor properties through their inhibition of key cancer promoting genes in this context. (PMID:24785261)
• MiR-1247-5p is overexpressed in castration resistant prostate cancer and targets MYCBP2. (PMID:25731699)
• miR-1247 plays an important role in progression of osteosarcoma. (PMID:25973030)
• our data suggest that CpG island hypermethylation of miR-1247 is responsible for its downregulation in pancreatic cancer, and ectopic expression of miR-1247 functions as a potential tumor suppressor targeting RCC2 in pancreatic cancer cells. (PMID:28460450)
• Low expression of MIR1247 is associated with hepatocellular carcinoma. (PMID:28586038)
• High-metastatic hepatocellular carcinoma cells secrete exosomal miR-1247-3p that directly targets B4GALT3, leading to activation of beta1-integrin-NF-kappaappaB metastatic signaling in fibroblasts resulting in lung cancer. (PMID:29335551)
• Our findings suggested miR-1247 directly targeted to repress ZNF346 expression, thus suppressing the progression of neuroblastoma, which might be a novel therapeutic target against neuroblastoma. (PMID:29793538)
• these results provide the first clues regarding the role of miR-1247 might be a potential therapeutic agent and diagnostic marker of bladder cancer by inhibiting RAB36 expression. (PMID:29872024)
• miR-1247-5p was related to the biological behaviour of breast tumour and prognosis of patients with breast cancer (PMID:30175411)
• Data show that Dishevelled 1 (DVL1) was a direct target of miR-1247-5p. (PMID:30249392)
• In bladder tumor cells circUBXN7 serves as a competitive endogenous RNA of miR-1247-3p to elevate B4GALT3 expression, consequently inhibiting cell viability and invasion. (PMID:30312173)
• MYCBP2, a member of the c-myc oncogene family, is a direct functional target of miR-1247. Furthermore, in colorectal cancer patients, MYCBP2 protein levels are associated with miR-1247 levels and survival (PMID:30318507)
• as a consequence of miR-1247 downregulation, we observed a correlated increased expression level of neuropilin-1, a miR-1247 target involved as a coreceptor in the epidermal growth factor receptor signaling (PMID:30378132)
• Circ_0070934 promotes cell growth, migration and invasion and inhibits cell apoptosis in cutaneous squamous cell carcinoma. Circ_0070934 could sponge miR-1238 and miR-1247-5p. The oncogenic function of circular RNA circ_0070934 is attributed to its suppression of miR-1238 and miR-1247-5p. (PMID:30967263)
• MicroRNA-1247 inhibits the viability and metastasis of osteosarcoma cells via targeting NRP1 and mediating Wnt/beta-catenin pathway. (PMID:31539113)
• The Potential Role of Selected miRNA in Uveal Melanoma Primary Tumors as Early Biomarkers of Disease Progression. (PMID:32131485)
• MiR-1247-5p Functions as a Tumor Suppressor in Human Astroglioma Cells by Targeting CDC14B. (PMID:32366555)
• Characterization of Adrenal miRNA-Based Dysregulations in Cushing’s Syndrome. (PMID:35887024)
• Crucial role of hsa-mir-503, hsa-mir-1247, and their validation in prostate cancer. (PMID:37980162)
• Tumor-derived exosomal miR-1247-3p promotes angiogenesis in bladder cancer by targeting FOXO1. (PMID:38073044)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.