MIR1248

Summary

MIR1248 (microRNA 1248, HGNC:35314) is a microRNA gene on chromosome 3q27.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302143 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35314
Approved symbol	MIR1248
Name	microRNA 1248
Location	3q27.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1248
Ensembl gene	ENSG00000283958
Ensembl biotype	miRNA
Entrez	100302143
RNAcentral	URS000075EAF7 — ncRNA, 106 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000629190

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000629190 — 1 exons

Exon	Start	End
ENSE00003765426	186786672	186786777

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 98.66.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.66	gold quality
lung	UBERON:0002048	95.21	gold quality
liver	UBERON:0002107	92.92	gold quality
heart	UBERON:0000948	87.15	gold quality
heart left ventricle	UBERON:0002084	77.36	gold quality
adult mammalian kidney	UBERON:0000082	74.51	gold quality
blood	UBERON:0000178	72.94	gold quality
pancreas	UBERON:0001264	71.61	gold quality
islet of Langerhans	UBERON:0000006	69.84	gold quality
nucleus accumbens	UBERON:0001882	66.03	gold quality
gastrocnemius	UBERON:0001388	65.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Diabetes-induced glucolipotoxicity impairs wound healing ability of adipose-derived stem cells-through the miR-1248/CITED2/HIF-1alpha pathway. (PMID:32294623)
• Downregulation of circEPSTI1 represses the proliferation and invasion of non-small cell lung cancer by inhibiting TRIM24 via miR-1248 upregulation. (PMID:32828310)
• Hsa-miR-1248 suppressed the proliferation, invasion and migration of colorectal cancer cells via inhibiting PSMD10. (PMID:36028821)
• Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated metastasis and cisplatin resistance in cervical cancer. (PMID:37431919)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.