MIR1249

Summary

MIR1249 (microRNA 1249, HGNC:35315) is a microRNA gene on chromosome 22q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302149 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35315
Approved symbol	MIR1249
Name	microRNA 1249
Location	22q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1249
Ensembl gene	ENSG00000221598
Ensembl biotype	miRNA
Entrez	100302149
RNAcentral	URS000075BEA3 — miRNA, 66 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408671

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408671 — 1 exons

Exon	Start	End
ENSE00001565306	45200954	45201019

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 95.60.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
prefrontal cortex	UBERON:0000451	95.60	gold quality
sural nerve	UBERON:0015488	94.81	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.97	gold quality
frontal cortex	UBERON:0001870	91.83	gold quality
right frontal lobe	UBERON:0002810	91.66	gold quality
duodenum	UBERON:0002114	91.22	gold quality
cerebral cortex	UBERON:0000956	89.57	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	89.48	gold quality
amygdala	UBERON:0001876	88.34	gold quality
Ammon’s horn	UBERON:0001954	88.33	gold quality
anterior cingulate cortex	UBERON:0009835	88.25	gold quality
skeletal muscle tissue	UBERON:0001134	88.14	gold quality
vermiform appendix	UBERON:0001154	87.76	gold quality
hypothalamus	UBERON:0001898	87.67	gold quality
putamen	UBERON:0001874	87.55	gold quality
caudate nucleus	UBERON:0001873	87.35	gold quality
substantia nigra	UBERON:0002038	86.94	gold quality
nucleus accumbens	UBERON:0001882	86.87	gold quality
brain	UBERON:0000955	85.66	gold quality
right hemisphere of cerebellum	UBERON:0014890	84.56	gold quality
lower esophagus mucosa	UBERON:0035834	83.94	gold quality
blood	UBERON:0000178	83.03	gold quality
cerebellar hemisphere	UBERON:0002245	82.54	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	81.13	gold quality
smooth muscle tissue	UBERON:0001135	80.67	gold quality
rectum	UBERON:0001052	79.87	gold quality
adrenal tissue	UBERON:0018303	79.57	gold quality
monocyte	CL:0000576	79.48	gold quality
right adrenal gland cortex	UBERON:0035827	79.28	gold quality
muscle of leg	UBERON:0001383	78.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.35

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Two miRNAs, miR-584-5p and miR-1249, that matched with the PB2 binding sequence, dramatically down-regulated PB2 expression, and inhibited replication of H5N1 and H1N1 influenza A virus strains in A549 cells. (PMID:28609011)
• MiR-1249 was downregulated in colorectal cancer tissues and cell lines, and was negative correlate with pN stage, pM stage, TNM stage and overall survival. P53-induced miR-1249 inhibited colorectal cancer growth, metastasis and angiogenesis in vitro and vivo. (PMID:30755600)
• Knockdown miR-1249-3p expression inhibits HCC cell proliferation, colony formation, and cell invasion through regulating HNRNPK in vitro. (PMID:31429522)
• MicroRNA-1249 targets four-jointed box kinase 1 and reduces cell proliferation, migration and invasion of colon adenocarcinoma. (PMID:32159255)
• miR-1249-5p regulates the osteogenic differentiation of ADSCs by targeting PDX1. (PMID:33407691)
• Identification of a Novel circ_0010235/miR-1249-3p/HOXA13 Axis in Lung Adenocarcinoma. (PMID:35076814)
• MiR-1249 on Endothelial Extracellular Vesicles Mediates Cigarette Smoke-Induced Pulmonary Hypertension by Inhibiting HDAC10 (Histone Deacetylase 10)-NFkappaB (Nuclear Factor kappaB)-CaSR (Calcium-Sensing Receptor) Cascade. (PMID:36252137)
• Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5. (PMID:36808266)
• Hsa-microRNA-1249-3p/Homeobox A13 axis modulates the expression of beta-catenin gene in human epithelial cells. (PMID:38129477)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.