MIR1250

Summary

MIR1250 (microRNA 1250, HGNC:35316) is a microRNA gene on chromosome 17q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302229 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35316
Approved symbol	MIR1250
Name	microRNA 1250
Location	17q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1250
Ensembl gene	ENSG00000221025
Ensembl biotype	miRNA
Entrez	100302229
RNAcentral	URS000075AF0B — miRNA, 113 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408098

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408098 — 1 exons

Exon	Start	End
ENSE00001564733	81133196	81133308

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 95.02.

Top tissues by expression

100 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	95.02	gold quality
cerebellar hemisphere	UBERON:0002245	93.09	gold quality
cerebellar cortex	UBERON:0002129	93.02	gold quality
blood	UBERON:0000178	89.87	gold quality
lower esophagus mucosa	UBERON:0035834	88.06	gold quality
pituitary gland	UBERON:0000007	86.93	gold quality
body of pancreas	UBERON:0001150	86.26	gold quality
pancreas	UBERON:0001264	85.74	gold quality
adenohypophysis	UBERON:0002196	84.74	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	83.49	gold quality
right frontal lobe	UBERON:0002810	83.35	gold quality
prefrontal cortex	UBERON:0000451	83.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	83.30	gold quality
frontal cortex	UBERON:0001870	83.17	gold quality
brain	UBERON:0000955	81.92	gold quality
granulocyte	CL:0000094	81.57	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	81.16	gold quality
cerebral cortex	UBERON:0000956	80.86	gold quality
Ammon’s horn	UBERON:0001954	80.34	gold quality
corpus callosum	UBERON:0002336	79.00	gold quality
hypothalamus	UBERON:0001898	78.97	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.92	gold quality
monocyte	CL:0000576	78.88	gold quality
right lung	UBERON:0002167	78.20	gold quality
anterior cingulate cortex	UBERON:0009835	77.87	gold quality
putamen	UBERON:0001874	77.40	gold quality
substantia nigra	UBERON:0002038	77.25	gold quality
tibial nerve	UBERON:0001323	77.05	gold quality
caudate nucleus	UBERON:0001873	76.92	gold quality
multicellular organism	UBERON:0000468	76.65	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-1250-5p is a novel tumor suppressive intronic miRNA hypermethylated in non-Hodgkin’s lymphoma: novel targets with impact on ERK signaling and cell migration. (PMID:34044822)
• A long non-coding RNA, ELFN1-AS1, sponges miR-1250 to upregulate MTA1 to promote cell proliferation, migration and invasion, and induce apoptosis in colorectal cancer. (PMID:34337713)
• LINC01232 targeting miR-1250-3p/MSH2 axis attenuates mesangial cell proliferation and fibrosis in diabetic nephropathy. (PMID:37642881)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.