MIR1251

Summary

MIR1251 (microRNA 1251, HGNC:35317) is a microRNA gene on chromosome 12q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302289 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35317
Approved symbol	MIR1251
Name	microRNA 1251
Location	12q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1251
Ensembl gene	ENSG00000221479
Ensembl biotype	miRNA
Entrez	100302289
RNAcentral	URS000075C678 — miRNA, 70 nt, 22 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408552

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408552 — 1 exons

Exon	Start	End
ENSE00001565187	97491909	97491978

Expression profiles

Bgee: expression breadth broad, 53 present calls, max score 79.39.

Top tissues by expression

53 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	79.39	gold quality
kidney	UBERON:0002113	77.50	gold quality
body of uterus	UBERON:0009853	74.95	gold quality
islet of Langerhans	UBERON:0000006	74.14	gold quality
right uterine tube	UBERON:0001302	73.59	gold quality
right lobe of thyroid gland	UBERON:0001119	73.52	gold quality
heart	UBERON:0000948	72.71	gold quality
left lobe of thyroid gland	UBERON:0001120	71.15	gold quality
fallopian tube	UBERON:0003889	70.94	gold quality
body of pancreas	UBERON:0001150	70.63	gold quality
thyroid gland	UBERON:0002046	70.36	gold quality
stomach	UBERON:0000945	70.07	gold quality
apex of heart	UBERON:0002098	69.43	gold quality
right atrium auricular region	UBERON:0006631	69.32	gold quality
intestine	UBERON:0000160	69.31	gold quality
hypothalamus	UBERON:0001898	68.35	gold quality
body of stomach	UBERON:0001161	68.14	gold quality
right lobe of liver	UBERON:0001114	68.12	gold quality
pituitary gland	UBERON:0000007	67.37	gold quality
substantia nigra	UBERON:0002038	67.08	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.83	gold quality
adenohypophysis	UBERON:0002196	66.38	gold quality
tibial artery	UBERON:0007610	65.99	gold quality
right frontal lobe	UBERON:0002810	65.88	gold quality
blood	UBERON:0000178	65.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.15	gold quality
amygdala	UBERON:0001876	65.13	gold quality
vagina	UBERON:0000996	65.04	gold quality
colon	UBERON:0001155	65.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• these results suggest that miR-1251-5p functions as an oncogene to suppress TBCC and alpha/beta-tubulin expression. Thus, the miR-1251-5p/TBCC/alpha/beta-tubulin axis may be targeted for ovarian cancer treatment. (PMID:31278033)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir1251	ENSMUSG00000093227

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.