MIR1252

Summary

MIR1252 (microRNA 1252, HGNC:35365) is a microRNA gene on chromosome 12q21.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302136 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35365
Approved symbol	MIR1252
Name	microRNA 1252
Location	12q21.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1252
Ensembl gene	ENSG00000221788
Ensembl biotype	miRNA
Entrez	100302136
RNAcentral	URS000075CAE4 — miRNA, 65 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408861

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408861 — 1 exons

Exon	Start	End
ENSE00001565496	79419257	79419321

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 78.43.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	78.43	gold quality
blood	UBERON:0000178	78.26	gold quality
heart	UBERON:0000948	76.20	gold quality
lung	UBERON:0002048	74.58	gold quality
islet of Langerhans	UBERON:0000006	73.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	72.92	gold quality
stomach	UBERON:0000945	72.78	gold quality
tibial artery	UBERON:0007610	72.55	gold quality
right atrium auricular region	UBERON:0006631	72.33	gold quality
heart left ventricle	UBERON:0002084	70.44	gold quality
adult mammalian kidney	UBERON:0000082	69.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.54	gold quality
vagina	UBERON:0000996	68.10	gold quality
right coronary artery	UBERON:0001625	67.76	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.26	gold quality
granulocyte	CL:0000094	67.25	gold quality
ascending aorta	UBERON:0001496	67.17	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.09	gold quality
intestine	UBERON:0000160	66.82	gold quality
ectocervix	UBERON:0012249	66.74	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.68	gold quality
liver	UBERON:0002107	66.66	gold quality
upper lobe of left lung	UBERON:0008952	66.08	gold quality
nucleus accumbens	UBERON:0001882	65.87	gold quality
esophagus mucosa	UBERON:0002469	65.80	gold quality
endometrium	UBERON:0001295	65.69	gold quality
Ammon’s horn	UBERON:0001954	65.68	gold quality
myometrium	UBERON:0001296	65.50	gold quality
substantia nigra	UBERON:0002038	65.33	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• CircABCB10 promotes non-small cell lung cancer cell proliferation and migration by regulating the miR-1252/FOXR2 axis. (PMID:30417418)
• The LncRNA AL161431.1 targets miR-1252-5p and facilitates cellular proliferation and migration via MAPK signaling in endometrial carcinoma. (PMID:32196580)
• Long noncoding RNA LINC00520 accelerates lung adenocarcinoma progression via miR-1252-5p/FOXR2 pathway. (PMID:33464477)
• MicroRNA-1252-5p, regulated by Myb, inhibits invasion and epithelial-mesenchymal transition of pancreatic cancer cells by targeting NEDD9. (PMID:34314382)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.