MIR1253

Summary

MIR1253 (microRNA 1253, HGNC:35318) is a microRNA gene on chromosome 17p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302208 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35318
Approved symbol	MIR1253
Name	microRNA 1253
Location	17p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1253
Ensembl gene	ENSG00000221200
Ensembl biotype	miRNA
Entrez	100302208
RNAcentral	URS0000708133 — miRNA, 105 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408273

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408273 — 1 exons

Exon	Start	End
ENSE00001564908	2748078	2748182

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 70.17.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	70.17	gold quality
monocyte	CL:0000576	69.21	gold quality
esophagus mucosa	UBERON:0002469	68.22	gold quality
ovary	UBERON:0000992	67.85	gold quality
tibial artery	UBERON:0007610	65.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.81	gold quality
omental fat pad	UBERON:0010414	64.09	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.31	gold quality
stomach	UBERON:0000945	62.15	gold quality
tibial nerve	UBERON:0001323	61.30	gold quality
transverse colon	UBERON:0001157	60.69	gold quality
Ammon’s horn	UBERON:0001954	60.26	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.07	gold quality
right frontal lobe	UBERON:0002810	59.49	gold quality
cerebral cortex	UBERON:0000956	59.44	gold quality
amygdala	UBERON:0001876	58.84	gold quality
small intestine Peyer’s patch	UBERON:0003454	58.62	gold quality
putamen	UBERON:0001874	58.47	gold quality
cerebellar hemisphere	UBERON:0002245	57.46	gold quality
corpus callosum	UBERON:0002336	57.45	gold quality
right hemisphere of cerebellum	UBERON:0014890	56.94	gold quality
anterior cingulate cortex	UBERON:0009835	56.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	56.19	gold quality
nucleus accumbens	UBERON:0001882	53.67	gold quality
right uterine tube	UBERON:0001302	53.43	gold quality
pituitary gland	UBERON:0000007	50.68	gold quality
hypothalamus	UBERON:0001898	50.03	gold quality
caudate nucleus	UBERON:0001873	48.92	gold quality
left testis	UBERON:0004533	39.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• The inhibitory effects of miR-1253 on the growth and metastasis of NSCLC cells were attenuated and phenocopied by WNT5A (long) overexpression and knockdown, respectively. (PMID:29415994)
• circNASP contributes to malignant behaviors of osteosarcoma cells by miR-1253/FOXF1 pathway. (PMID:29678578)
• lncRNA FOXC2-AS1 accelerated the tumor progression of prostate cancer cells by regulating the proliferation and tumor growth through miR-1253/EZH2 axis. (PMID:30389560)
• Mechanistically, circular RNA circ_0030235 directly sponges miR-1253 and miR-1294 in pancreatic ductal adenocarcinoma cells. (PMID:30591218)
• MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). (PMID:32145124)
• miR-1253, a novel tumor suppressor gene in colon cancer, is associated with poor patients prognosis. (PMID:33837882)
• MicroRNA-1253 Suppresses Cell Proliferation Migration and Invasion of Osteosarcoma by Targeting MMP9. (PMID:34036868)
• Hsa_circ_0000190 Promotes NSCLC Cell Resistance to Cisplatin via the Modulation of the miR-1253/IL-6 Axis. (PMID:38440120)

Cross-species orthologs

0 orthologs

Paralogs (1): hsa-mir-1253 (ENSG00000272920)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.