MIR1255A

Summary

MIR1255A (microRNA 1255a, HGNC:35320) is a microRNA gene on chromosome 4q24.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302193 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35320
Approved symbol	MIR1255A
Name	microRNA 1255a
Location	4q24
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1255a
Ensembl gene	ENSG00000221265
Ensembl biotype	miRNA
Entrez	100302193
RNAcentral	URS000075C3F5 — miRNA, 113 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408338

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408338 — 1 exons

Exon	Start	End
ENSE00001564973	101330302	101330414

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 86.52.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	86.52	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	86.15	gold quality
adrenal tissue	UBERON:0018303	82.94	gold quality
bone marrow	UBERON:0002371	82.19	gold quality
kidney	UBERON:0002113	81.43	gold quality
blood	UBERON:0000178	80.72	gold quality
adult mammalian kidney	UBERON:0000082	79.67	gold quality
monocyte	CL:0000576	79.12	gold quality
liver	UBERON:0002107	78.51	gold quality
calcaneal tendon	UBERON:0003701	78.04	gold quality
fundus of stomach	UBERON:0001160	77.49	gold quality
stomach	UBERON:0000945	76.48	gold quality
islet of Langerhans	UBERON:0000006	76.06	gold quality
muscle of leg	UBERON:0001383	75.51	gold quality
adrenal gland	UBERON:0002369	74.70	gold quality
body of pancreas	UBERON:0001150	74.25	gold quality
right lobe of liver	UBERON:0001114	72.25	gold quality
gastrocnemius	UBERON:0001388	71.61	gold quality
lung	UBERON:0002048	71.43	gold quality
endometrium	UBERON:0001295	71.34	gold quality
body of stomach	UBERON:0001161	70.54	gold quality
ascending aorta	UBERON:0001496	70.31	gold quality
left uterine tube	UBERON:0001303	70.06	gold quality
urinary bladder	UBERON:0001255	69.74	gold quality
intestine	UBERON:0000160	69.57	gold quality
body of uterus	UBERON:0009853	69.47	gold quality
left adrenal gland	UBERON:0001234	69.42	gold quality
right adrenal gland cortex	UBERON:0035827	69.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.23	gold quality
heart	UBERON:0000948	69.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer. (PMID:31763681)

Cross-species orthologs

0 orthologs

Paralogs (1): MIR1255B2 (ENSG00000221545)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.