MIR1255B1

Summary

MIR1255B1 (microRNA 1255b-1, HGNC:35366) is a microRNA gene on chromosome 4p14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313806 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35366
Approved symbol	MIR1255B1
Name	microRNA 1255b-1
Location	4p14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1255b-1
Ensembl gene	ENSG00000283207
Ensembl biotype	miRNA
Entrez	100313806
RNAcentral	URS000075C0B5 — miRNA, 63 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636325

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636325 — 1 exons

Exon	Start	End
ENSE00003800121	36426366	36426428

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 68.25.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
transverse colon	UBERON:0001157	68.25	gold quality
body of pancreas	UBERON:0001150	67.92	gold quality
tibial nerve	UBERON:0001323	62.54	gold quality
upper lobe of left lung	UBERON:0008952	57.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer. (PMID:31763681)
• Diagnostic significance of microRNA-1255b-5p in prostate cancer patients and its effect on cancer cell function. (PMID:34895055)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.