MIR1255B2

Summary

MIR1255B2 (microRNA 1255b-2, HGNC:35367) is a microRNA gene on chromosome 1q24.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313835 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35367
Approved symbol	MIR1255B2
Name	microRNA 1255b-2
Location	1q24.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1255b-2
Ensembl gene	ENSG00000221545
Ensembl biotype	miRNA
Entrez	100313835
RNAcentral	URS000075CA6D — miRNA, 67 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408618

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408618 — 1 exons

Exon	Start	End
ENSE00001565253	167998660	167998726

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 80.62.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	80.62	gold quality
blood	UBERON:0000178	78.66	gold quality
calcaneal tendon	UBERON:0003701	76.83	gold quality
monocyte	CL:0000576	76.49	gold quality
heart	UBERON:0000948	72.51	gold quality
gastrocnemius	UBERON:0001388	71.75	gold quality
heart left ventricle	UBERON:0002084	70.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.32	gold quality
endometrium	UBERON:0001295	69.65	gold quality
body of stomach	UBERON:0001161	69.07	gold quality
right lung	UBERON:0002167	68.71	gold quality
right atrium auricular region	UBERON:0006631	68.54	gold quality
stomach	UBERON:0000945	68.25	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.25	gold quality
right lobe of liver	UBERON:0001114	68.09	gold quality
amygdala	UBERON:0001876	67.19	gold quality
body of pancreas	UBERON:0001150	66.51	gold quality
skin of leg	UBERON:0001511	66.39	gold quality
tibial artery	UBERON:0007610	65.87	gold quality
vagina	UBERON:0000996	65.52	gold quality
esophagus mucosa	UBERON:0002469	64.97	gold quality
skin of abdomen	UBERON:0001416	64.94	gold quality
putamen	UBERON:0001874	64.92	gold quality
ascending aorta	UBERON:0001496	64.87	gold quality
thoracic mammary gland	UBERON:0005200	64.60	gold quality
body of uterus	UBERON:0009853	64.42	gold quality
transverse colon	UBERON:0001157	64.13	gold quality
intestine	UBERON:0000160	63.95	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.88	gold quality
right frontal lobe	UBERON:0002810	63.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Identification of exosomal miR-455-5p and miR-1255a as therapeutic targets for breast cancer. (PMID:31763681)
• Diagnostic significance of microRNA-1255b-5p in prostate cancer patients and its effect on cancer cell function. (PMID:34895055)

Cross-species orthologs

0 orthologs

Paralogs (1): MIR1255A (ENSG00000221265)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.