MIR1256

Summary

MIR1256 (microRNA 1256, HGNC:35321) is a microRNA gene on chromosome 1p36.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302155 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35321
Approved symbol	MIR1256
Name	microRNA 1256
Location	1p36.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1256
Ensembl gene	ENSG00000221808
Ensembl biotype	miRNA
Entrez	100302155
RNAcentral	URS000075B8A9 — miRNA, 119 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408881

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408881 — 1 exons

Exon	Start	End
ENSE00001565516	20988314	20988432

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 83.17.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	83.17	gold quality
adrenal tissue	UBERON:0018303	82.15	gold quality
blood	UBERON:0000178	75.74	gold quality
kidney	UBERON:0002113	75.40	gold quality
adrenal gland	UBERON:0002369	74.73	gold quality
stomach	UBERON:0000945	74.72	gold quality
endometrium	UBERON:0001295	74.58	gold quality
adult mammalian kidney	UBERON:0000082	74.50	gold quality
bone marrow	UBERON:0002371	73.32	gold quality
gastrocnemius	UBERON:0001388	72.91	gold quality
body of pancreas	UBERON:0001150	70.74	gold quality
heart	UBERON:0000948	69.97	gold quality
esophagus mucosa	UBERON:0002469	69.10	gold quality
right adrenal gland	UBERON:0001233	69.03	gold quality
lung	UBERON:0002048	68.98	gold quality
tibial artery	UBERON:0007610	68.89	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.88	gold quality
left coronary artery	UBERON:0001626	67.51	gold quality
heart left ventricle	UBERON:0002084	67.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.42	gold quality
ascending aorta	UBERON:0001496	67.39	gold quality
colon	UBERON:0001155	67.36	gold quality
omental fat pad	UBERON:0010414	67.34	gold quality
calcaneal tendon	UBERON:0003701	67.15	gold quality
body of stomach	UBERON:0001161	67.08	gold quality
intestine	UBERON:0000160	66.85	gold quality
adipose tissue	UBERON:0001013	66.70	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.70	gold quality
right atrium auricular region	UBERON:0006631	66.65	gold quality
putamen	UBERON:0001874	66.61	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Upregulation of serum miR-1246 is associated with esophageal squamous cell carcinoma. (PMID:23361059)
• We provide evidence that low miR-1256 expression was associated with the progression of colorectal cancer (PMID:30536313)
• Data show that circular RNA circ-DCAF6 (DDB1 and CUL4 associated factor 6) exerts oncogenic properties by downregulating miR-1231 and miR-1256. (PMID:31226266)
• Our results revealed that circHECTD1 is a glutaminolysis-associated circRNA that promotes gastric cancer (GC) progression. The circHECTD1/miR-1256/USP5 axis could thus be used as a therapeutic target for GC. (PMID:31371702)
• Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility. (PMID:33534179)
• CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer. (PMID:36738282)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.