MIR1257

Summary

MIR1257 (microRNA 1257, HGNC:35322) is a microRNA gene on chromosome 20q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302168 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35322
Approved symbol	MIR1257
Name	microRNA 1257
Location	20q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1257
Ensembl gene	ENSG00000284193
Ensembl biotype	miRNA
Entrez	100302168
RNAcentral	URS000075DA8E — miRNA, 117 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408490

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408490 — 1 exons

Exon	Start	End
ENSE00001565125	61953546	61953662

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 77.57.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	77.57	gold quality
monocyte	CL:0000576	73.98	gold quality
heart left ventricle	UBERON:0002084	73.62	gold quality
duodenum	UBERON:0002114	73.30	gold quality
blood	UBERON:0000178	70.97	gold quality
muscle of leg	UBERON:0001383	70.90	gold quality
gastrocnemius	UBERON:0001388	69.41	gold quality
right ovary	UBERON:0002118	68.97	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.68	gold quality
tibial artery	UBERON:0007610	68.47	gold quality
ascending aorta	UBERON:0001496	68.40	gold quality
anterior cingulate cortex	UBERON:0009835	68.13	gold quality
left coronary artery	UBERON:0001626	67.87	gold quality
pituitary gland	UBERON:0000007	67.17	gold quality
minor salivary gland	UBERON:0001830	67.10	gold quality
ovary	UBERON:0000992	66.99	gold quality
hypothalamus	UBERON:0001898	66.80	gold quality
left ovary	UBERON:0002119	66.10	gold quality
substantia nigra	UBERON:0002038	65.90	gold quality
body of stomach	UBERON:0001161	65.80	gold quality
right atrium auricular region	UBERON:0006631	65.53	gold quality
esophagus mucosa	UBERON:0002469	65.13	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.92	gold quality
skin of abdomen	UBERON:0001416	64.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.67	gold quality
ectocervix	UBERON:0012249	64.61	gold quality
body of pancreas	UBERON:0001150	64.49	gold quality
adrenal gland	UBERON:0002369	64.13	gold quality
small intestine	UBERON:0002108	63.76	gold quality
lower esophagus	UBERON:0013473	63.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.