MIR1258

Summary

MIR1258 (microRNA 1258, HGNC:35323) is a microRNA gene on chromosome 2q31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302172 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35323
Approved symbol	MIR1258
Name	microRNA 1258
Location	2q31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1258
Ensembl gene	ENSG00000221240
Ensembl biotype	miRNA
OMIM	614488
Entrez	100302172
RNAcentral	URS000075ADAC — miRNA, 73 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408313

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408313 — 1 exons

Exon	Start	End
ENSE00001564948	179860836	179860908

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 78.77.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	78.77	gold quality
liver	UBERON:0002107	69.08	gold quality
right lobe of liver	UBERON:0001114	68.30	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.83	gold quality
esophagus mucosa	UBERON:0002469	65.69	gold quality
tibial nerve	UBERON:0001323	64.96	gold quality
ascending aorta	UBERON:0001496	64.60	gold quality
right ovary	UBERON:0002118	63.52	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.74	gold quality
putamen	UBERON:0001874	62.58	gold quality
right frontal lobe	UBERON:0002810	61.78	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.60	gold quality
caudate nucleus	UBERON:0001873	61.56	gold quality
right hemisphere of cerebellum	UBERON:0014890	60.76	gold quality
cerebellar hemisphere	UBERON:0002245	60.49	gold quality
nucleus accumbens	UBERON:0001882	59.80	gold quality
left testis	UBERON:0004533	43.30	gold quality
right testis	UBERON:0004534	42.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 15)

• the expression levels of HPSE and miR-1258 in NSCLC tissue are closely related. In HPSE-positive samples, the expression levels of miR-1258 were relatively low; in HPSE-negative samples, the expression levels of miR-1258 were relatively high. (PMID:22488243)
• MiR-1258 may play an important role in breast cancer development and progression by regulating the expression of HPSE, and they might be potential prognostic biomarkers for breast cancer. (PMID:23415719)
• Collectively, the data demonstrate that, by regulating cellular miR-1258, Nef may inhibit Kaposi’s sarcoma-associated herpesvirus replication to promote viral latency and contribute to the pathogenesis of AIDS-related malignancies. (PMID:24554664)
• Loss of miR-1258 contributes to carcinogenesis and progression of liver cancer through targeting CKS1B. (PMID:27270326)
• These results enable the involvement of three miRNAs (miR-132, miR-137, miR-1258) and the methylation of the genes that encode them in the pathogenesis of breast cancer to be suggested. (PMID:27830681)
• that miR-1258 can suppress NSCLC progression by targeting the GRB2/Ras/Erk pathway (PMID:30069987)
• MiR-1258 may function as a suppressive factor by negatively controlling E2F8 (PMID:30144184)
• Low MicroRNA-1258 expression is associated with oral squamous cell carcinoma. (PMID:30734471)
• miR-1258 suppresses cell proliferation as well as regulating the cell cycle by targeting AKT3 in osteosarcoma. (PMID:30737029)
• Considering the highly increased levels of CKS1B and decreased expression of miR-1258 in tumors from CRC patients, these findings suggest that miR-1258 may play tumor-suppressive roles by targeting CKS1B expression in CRC. (PMID:31717435)
• MiR-1258 promotes the apoptosis of cervical cancer cells by regulating the E2F1/P53 signaling pathway. (PMID:31917289)
• Frequent methylation of the tumour suppressor miR-1258 targeting PDL1: implication in multiple myeloma-specific cytotoxicity and prognostification. (PMID:32079038)
• miR-1258 Regulates Cell Proliferation and Cell Cycle to Inhibit the Progression of Breast Cancer by Targeting E2F1. (PMID:32733928)
• Circ_0046600 promotes hepatocellular carcinoma progression via up-regulating SERBP1 through sequestering miR-1258. (PMID:34784519)
• MicroRNA-1258 suppresses oxidative stress and inflammation in septic acute lung injury through the Pknox1-regulated TGF-beta1/SMAD3 cascade. (PMID:38640751)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.