MIR125A

Summary

MIR125A (microRNA 125a, HGNC:31505) is a microRNA gene on chromosome 19q13.41.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406910 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31505
Approved symbol	MIR125A
Name	microRNA 125a
Location	19q13.41
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-125a
Ensembl gene	ENSG00000208008
Ensembl biotype	miRNA
OMIM	611191
Entrez	406910
RNAcentral	URS000075D168 — miRNA, 86 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385273

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385273 — 1 exons

Exon	Start	End
ENSE00001500279	51693254	51693339

Expression profiles

Bgee: expression breadth tissue_specific, 5 present calls, max score 69.68.

Top tissues by expression

5 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	69.68	gold quality
stomach	UBERON:0000945	65.64	gold quality
left uterine tube	UBERON:0001303	63.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.02	gold quality
skin of leg	UBERON:0001511	46.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• study identified an miR-125a SNP that significantly blocks the processing of pri-miRNA to pre-miRNA, in addition to reducing miRNA-mediated translational suppression (PMID:17400653)
• Studies show that a germline mutation in mature miR-125a is highly associated with breast cancer tumorigenesis, suggesting that miR-125a is likely to function as a tumour suppressor gene in cancer: [microRNA-125a] (PMID:19411564)
• examination of lung cancer samples revealed a significant correlation of miR-125a-5p repression with lung carcinogenesis (PMID:19702827)
• Findings add miRNA-125a to the growing list of miRNA with oncogenic targets. (PMID:19818772)
• miR-125a may function as a tumor suppressor for breast cancer, with HuR as a direct and functional target. (PMID:19875930)
• We identify AT-rich interactive domain 3B (ARID3B) as a target of miR-125a and demonstrate that ARID3B is overexpressed in human ovarian cancer (PMID:19881956)
• miR-125a-3p and miR-125a-5p play distinct roles in regulation of invasive and metastatic capabilities of lung cancer cells. (PMID:20569443)
• demonstrated that these microRNAs directly target the 3’ untranslated region of PDPN and inhibit invasion, apoptosis, and proliferation of glioblastomas (PMID:20665731)
• miR-125a-5p is a meaningful prognostic marker. Furthermore, miR-125a-5p mimic alone or in combination with trastuzumab could be a novel therapeutic approach against gastric cancer. (PMID:21220473)
• The microRNA hsa-miR-125a-5p was shown to interfere with the viral translation, down-regulating the expression of the hepatitis B virus surface antigen. (PMID:21317190)
• HSA-miR-125a-5p induces apoptosis via a p53-dependent pathway in human lung cancer cells. (PMID:21777146)
• two common polymorphisms in pre-miR-125a might contribute to the genetic predisposition to recurrent pregnancy loss by disrupting the production of miR-125a, which consequently interfered in the expression and function of target genes of miR-125a (PMID:21788734)
• The rs12975333 variant in the miR-125a and breast cancer risk in Germany, Italy, Australia and Spain. (PMID:21931172)
• Demonstrate that miR-125a-3p is a meaningful prognostic marker in gastric cancer. (PMID:22322911)
• miR-125 potentiates early neural specification of human embryonic stem cells (PMID:22357933)
• MicroRNAs miR-125a and miR-125b constitutively activate the NF-kappaB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20). (PMID:22550173)
• new function of miR-125a by targeting gene glypican-4 in cell growth process (PMID:22644326)
• Differential expression of microRNAs miR-21, miR-31, miR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck. (PMID:22690848)
• Down regulation of TP53 and upregulation of miR-125a during in-vitro passages of human amniotic fluid-derived mesenchymal stromal cells (hAMSC) may act as an indicator of the stemness of hAMSC. (PMID:22747700)
• MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF-A. (PMID:22768249)
• SIRT7 inhibits transcriptional activation of p21WAF1/Cip1 by way of repression of miR-125a-5p and miR-125b. (PMID:23079745)
• study suggested that miR-125a/b expression plays a key role in chemoresistance through upregulating ALDH1A3 and Mcl1 gene expression. (PMID:23327190)
• These results provide new insights into the role of the miR-125a family in lung cancer. (PMID:23525486)
• Data indicate that down-regulation of SMG1 expression is mediated by miRNA-125 binding to a microRNA response element in the 3’ untranslated region of SMG1 mRNA, which leads to degradation of the SMG1 mRNA. (PMID:23583196)
• This study demonistrated that miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux (PMID:23595744)
• MicroRNA-125a-3p reduces cell proliferation and migration by targeting Fyn. (PMID:23606749)
• MiR-125a-5p/125b can be considered among the therapeutic targets in HER2-positive esophageal and gastric adenocarcinoma. (PMID:23618359)
• Biogenesis, evolution and functional targets of microRNA-125a. (PMID:23783428)
• in HBsAg/anti-HBe-positive patients, the liver hsa-miR-125a-5p level correlated with liver and plasma HBV-DNA values and was associated to a more severe disease progression. (PMID:23843939)
• hsa-miR-125a-3p induces apoptosis not only via the p53 pathway in human lung cancer cells. (PMID:24044511)
• Circulating miR-125b is down-regulated in Alzheimer’s disease patients compared to controls. (PMID:24139697)
• Data showed previously unrecognized subclonal heterogeneity within the CD38+ fraction of CD38- CLL patients with low-risk FISH findings and suggested an association between down-regulated miR-125a-5p expression, genetic complexity and worse outcome. (PMID:24334759)
• miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. (PMID:24360988)
• In this review we describe the potential role of miR-125b and miR-34a in cervical carcinogenesis, including interaction with HPV and mechanism of deregulation (PMID:24402874)
• miR-125a regulates cell cycle, proliferation, and apoptosis by targeting the ErbB pathway in acute myeloid leukemia. (PMID:24484870)
• Adaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men (PMID:24675842)
• miR-125a inhibits erythroid differentiation in leukemia and MDS cell lines. (PMID:24690917)
• Ectopic expression of micro-RNA-1, 21 and 125a in peripheral blood immune cells is associated with chronic hepatitis B infection. (PMID:24737570)
• our data indicate that miR-125a-5p antagonism results in the activation of p53 pathway in multiple myeloma cells, underlying the crucial role of this miRNA in the biopathology of multiple myeloma (PMID:24819167)
• Overall, the available data depict a self-inhibitory feedback loop in which HBV, through HBx, increases the expression of miR-125a, that in turn interferes with expression of HBV surface antigen, thus repressing viral replication. (PMID:24824183)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir125b-3	ENSDARG00000083557
mus_musculus	Mir125a	ENSMUSG00000065479
rattus_norvegicus	Mir125a	ENSRNOG00000035572

Paralogs (7): MIR99B (ENSG00000207550), MIR99A (ENSG00000207638), MIR10B (ENSG00000207744), MIR125B2 (ENSG00000207863), MIR125B1 (ENSG00000207971), MIR100 (ENSG00000207994), MIR10A (ENSG00000284038)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.