MIR125B2

Summary

MIR125B2 (microRNA 125b-2, HGNC:31507) is a microRNA gene on chromosome 21q21.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 406912 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:31507
Approved symbol	MIR125B2
Name	microRNA 125b-2
Location	21q21.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-125b-2
Ensembl gene	ENSG00000207863
Ensembl biotype	miRNA
OMIM	610105
Entrez	406912
RNAcentral	URS000058997A — ncRNA, 89 nt, 64 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385128

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385128 — 1 exons

Exon	Start	End
ENSE00001500134	16590237	16590325

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• The microRNA 125b2 can remarkably inhibit all-trans-retinoic acid-induced cell apoptosis. (PMID:19471102)
• MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression (PMID:20460378)
• expression of miR-125b suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR-125b may contribute to OC development (PMID:20658525)
• Results suggest that miR-125b-2 overexpression might confer glioblastoma stem cells resistance to TMZ. (PMID:21879257)
• Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. (PMID:21969554)
• Among possible numerous targets of miR-125b, we showed ARID3B (AT-rich interactive domain 3B) to be a novel target with roles in cell motility in breast cancer cells. (PMID:22307404)
• miR-125 potentiates early neural specification of human embryonic stem cells (PMID:22357933)
• Aberrantly expressed miR-125b contributes to HEC1B cells invasion partly through directly down-regulating ERBB2 protein expression in endometrioid endometrial cancer. (PMID:22460089)
• Down-regulation of miR-125b is associated with breast cancer. (PMID:22898264)
• The tumor-suppressive miR-125b served as a negative regulator of SUV39H1 (PMID:22991213)
• The miR-125b negatively regulates MAD1 expression by binding to its 3’UTR. (PMID:23099851)
• Down-regulation of miR-125b mainly in T cells may contribute to the pathogenesis of systemic lupus erythematosus by regulating ETS1 and STAT3 gene expression. (PMID:23305626)
• Our results indicate that miR-125b plays an important role in regulating the expression of ADAMTS-4 in human chondrocytes (PMID:23406982)
• Loss of miR125B expression is associated with prostate cancer (PMID:23503652)
• miR-125b-5p not only regulates tumor growth in cutaneous T-cell lymphomas, but also increases cellular resistance to proteasome inhibitors via modulation of MAD4. (PMID:23527180)
• MTA1 and miR-125b have antagonistic effects on the migration and invasion of NSCLC cells. (PMID:23718732)
• Dexamethasone-induced miR-125b induces cell death resistance mechanisms in multiple myeloma cells. (PMID:23759586)
• MiR-125b, miR-100 and miR-99a co-regulate vincristine resistance in childhood acute lymphoblastic leukemia. (PMID:23915977)
• OCT4 directly induces expression of miR-125b, which inhibits its direct target BAK1, leading to suppression of cervical cancer cell apoptosis. (PMID:23928699)
• miR-125b regulates glioma growth partly through Connexin43 protein. (PMID:24046143)
• miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9. (PMID:24098452)
• MiR-125b may have an oncogenic role in glioblastoma cells by promoting cell proliferation and inhibiting apoptosis. (PMID:24169356)
• PIK3CD is a target gene of miR-125b in Ewing’s sarcoma cells. RT-PCR and western blot assays identify over-expression of miR-125b that suppresses the expression of PIK3CD mRNA and protein. (PMID:24517182)
• microRNA125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis. (PMID:24604579)
• The expression of miR-106a was found to be upregulated, and miR-143 and miR-125b levels were found to be downregulated in colorectal tumor tissues compared with the normal tissues. (PMID:24746948)
• The miR-125 was found to downregulate glucose metabolism by directly targeting hexokinase II. (PMID:24865963)
• The results showed that tumor miR-125b is a potential independent adverse prognostic biomarker for recurrence and survival of patients with clear-cell renal cell carcinoma after nephrectomy. (PMID:25155155)
• MiR-125b functions as an oncogene by targeting downregulated PPP1CA and upregulated Rb phosphorylation in gastric cancer (PMID:25240408)
• Data indicate that MiR-125b regulates lens epithelial cell apoptosis by directly targeting p53. (PMID:25312242)
• miR-125b could be a potential biomarker with relatively high accuracy in the diagnosis of glioma as well as other human cancers (PMID:25416859)
• Expression of miR-125b is time-dependent and miR-125b plays a regulatory role of angiogenesis during wound healing after burns. (PMID:25468475)
• The co-expression of miR-125b and miR-99a contributed to the vincristine resistance to childhood acute megakaryoblastic leukemia cells due to actively transcribed miR99a/miR-125b locus on chromosome 21q21.1. (PMID:25571789)
• our data reveal that miR-19a-3p and miR-125b-5p target 5-Lipoxygenase in a cell type- and stimulus-specific manner. (PMID:25589070)
• Suggest that up-regulation of miR-125b or targeting Sema4C could serve as novel approaches to reverse chemotherapy resistance in breast cancers. (PMID:25605244)
• MicroRNA-125b upregulation confers aromatase inhibitor resistance and is a novel marker of poor prognosis in breast cancer (PMID:25633049)
• Results identified KLC2 as a novel target and functional mediator of miR-125b in non-small-cell lung cancer and revealed the post-transcriptional mechanism by which miR-125b might regulate KLC2 expression. (PMID:25668010)
• Data show that proto-oncogene protein HER-2 is directly regulated by microRNAs miR-125a and miR-125b in small cell lung cancer (SCLC). (PMID:25833836)
• Cisplatininduced expression of miR125a and miR125b inhibited cisplatininduced apoptosis in the TW03 cells by decreasing the protein expression levels of p53. (PMID:26017674)
• miR-21, miR-29a, and miR-125b may have a role in colorectal neoplasms (PMID:26038573)
• Our data suggest a mechanism by which CT-Cx43 may regulate cell proliferation by regulating mir-125b and p53 expression (PMID:26335100)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
danio_rerio	mir125a-2	ENSDARG00000081044
danio_rerio	mir125a-1	ENSDARG00000083123

Paralogs (7): MIR99B (ENSG00000207550), MIR99A (ENSG00000207638), MIR10B (ENSG00000207744), MIR125B1 (ENSG00000207971), MIR100 (ENSG00000207994), MIR125A (ENSG00000208008), MIR10A (ENSG00000284038)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.