MIR1260A

Summary

MIR1260A (microRNA 1260a, HGNC:35325) is a microRNA gene on chromosome 14q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302236 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35325
Approved symbol	MIR1260A
Name	microRNA 1260a
Location	14q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1260
Ensembl gene	ENSG00000221754
Ensembl biotype	miRNA
Entrez	100302236
RNAcentral	URS000075BD26 — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408827

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408827 — 1 exons

Exon	Start	End
ENSE00001565462	77266218	77266290

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 74.32.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	74.32	gold quality
blood	UBERON:0000178	73.47	gold quality
heart left ventricle	UBERON:0002084	73.47	gold quality
omental fat pad	UBERON:0010414	65.93	gold quality
body of stomach	UBERON:0001161	63.71	gold quality
ascending aorta	UBERON:0001496	63.05	gold quality
prostate gland	UBERON:0002367	61.55	gold quality
skin of leg	UBERON:0001511	60.73	gold quality
myometrium	UBERON:0001296	59.35	gold quality
transverse colon	UBERON:0001157	58.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	57.38	gold quality
left ovary	UBERON:0002119	57.13	gold quality
left adrenal gland cortex	UBERON:0035825	56.28	gold quality
muscle layer of sigmoid colon	UBERON:0035805	55.06	gold quality
thyroid gland	UBERON:0002046	52.89	gold quality
esophagus mucosa	UBERON:0002469	51.37	gold quality
left testis	UBERON:0004533	44.89	gold quality
caudate nucleus	UBERON:0001873	44.37	gold quality
cerebellar hemisphere	UBERON:0002245	43.92	silver quality
left lobe of thyroid gland	UBERON:0001120	43.91	gold quality
right testis	UBERON:0004534	25.33	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• Report decreased miR-1260 expression in human abdominal aortic aneurysms. (PMID:23746831)
• Data indicate that expression of miR-1260, -26a, -335*, -576-3p, -628-3p and -664 were consistently dysregulated in both whole blood and H1N1 infected cells. (PMID:24116168)
• PTPRK was identified as a direct target of miR-1260b, and PTPRK expression was inversely correlated with miR-1260b in non-small cell lung cancer cell lines and clinical tissues (PMID:29628123)
• We have found that miRs-1260 was over-expressed in PC patients compared to controls (p < 1 x 10(-5)). Moreover ROC curve for miRs-1260 showed a good performance to distinguish between controls group and PC samples with an area under the ROC curve of 0.897. (PMID:30250996)
• Clinical relevance and functional significance of cell-free microRNA-1260b expression profiles in infiltrative myxofibrosarcoma. (PMID:32523124)
• Pathway Analysis of Selected Circulating miRNAs in Plasma of Breast Cancer Patients: A Preliminary Study. (PMID:33023154)
• Comparative expression analysis of tRF-3001a and tRF-1003 with corresponding miRNAs (miR-1260a and miR-4521) and their network analysis with breast cancer biomarkers. (PMID:34661810)
• Plasma exosomal miR-1260a, miR-7977 and miR-192-5p as diagnostic biomarkers in epithelial ovarian cancer. (PMID:35893704)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.