MIR1260B

Summary

MIR1260B (microRNA 1260b, HGNC:38258) is a microRNA gene on chromosome 11q21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100422991 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:38258
Approved symbol	MIR1260B
Name	microRNA 1260b
Location	11q21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1260b
Ensembl gene	ENSG00000266192
Ensembl biotype	miRNA
OMIM	615372
Entrez	100422991
RNAcentral	URS0000759BF7 — miRNA, 89 nt, 11 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582890

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582890 — 1 exons

Exon	Start	End
ENSE00002719943	96341438	96341526

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 87.27.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	87.27	gold quality
bone marrow	UBERON:0002371	78.56	gold quality
duodenum	UBERON:0002114	76.67	gold quality
right frontal lobe	UBERON:0002810	76.29	gold quality
small intestine	UBERON:0002108	74.40	gold quality
blood	UBERON:0000178	70.97	gold quality
lung	UBERON:0002048	67.56	gold quality
multicellular organism	UBERON:0000468	66.01	gold quality
skin of abdomen	UBERON:0001416	65.98	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.64	gold quality
gastrocnemius	UBERON:0001388	64.51	gold quality
stomach	UBERON:0000945	61.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.54	gold quality
heart left ventricle	UBERON:0002084	61.49	gold quality
anterior cingulate cortex	UBERON:0009835	60.45	gold quality
islet of Langerhans	UBERON:0000006	58.87	gold quality
thyroid gland	UBERON:0002046	58.10	gold quality
putamen	UBERON:0001874	56.61	gold quality
body of stomach	UBERON:0001161	55.88	gold quality
adrenal gland	UBERON:0002369	51.66	gold quality
left ovary	UBERON:0002119	50.24	gold quality
nucleus accumbens	UBERON:0001882	50.15	gold quality
esophagus mucosa	UBERON:0002469	49.70	gold quality
testis	UBERON:0000473	49.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	47.27	gold quality
left adrenal gland	UBERON:0001234	41.21	gold quality
left adrenal gland cortex	UBERON:0035825	37.08	silver quality
left testis	UBERON:0004533	30.45	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 12)

• miR-1260b promoted renal cancer cell proliferation and invasion in renal cell carcinoma cells. (PMID:23591200)
• Data suggest genistein exerts its anti-tumour effect via downregulation of miR-1260b that targeted sRRP1 and Smad4 genes in prostate cancer cells. Expression of sFRP1 and Smad4 was modulated via DNA methylation or histone modifications in PC. (PMID:24504368)
• The miR-1260b expression in CRC was significantly higher than the expression levels in the corresponding para-carcinoma tissues (P<0.001). According to the expression levels of miR-1260b, 120 cases of CRC patients were classified into either the miR-1260b high expression group or the miR-1260b low expression group. (PMID:27399918)
• This pilot study suggests that miR1246 and miR4644 in salivary exosomes could be candidate biomarkers for pancreatobiliary tract cancer. (PMID:27573701)
• Regulator of G-protein signaling 22 (RGS22) was identified as a direct target of miR-1260b and was inhibited by miR-1260b. Knockdown of RGS22 increased proliferation of hepatocellular carcinoma cells. (PMID:29038925)
• Study is the first to illustrate that miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate NSCLC cell proliferation and apoptosis, and is a potential biomarker and therapeutic target for NSCLC. (PMID:30737371)
• Hypoxia-induced miR-1260b regulates vascular smooth muscle cell proliferation by targeting GDF11. (PMID:31818357)
• Exosome-mediated transfer of miR-1260b promotes cell invasion through Wnt/beta-catenin signaling pathway in lung adenocarcinoma. (PMID:32026462)
• Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2. (PMID:34321461)
• MiR-1260b protects against LPS-induced degenerative changes in nucleus pulposus cells through targeting TCF7L2. (PMID:35165858)
• Promotion of tumorigenesis by miR-1260b-targeting CASP8: Potential diagnostic and prognostic marker for breast cancer. (PMID:35325509)
• miRNA-1260b Promotes Breast Cancer Cell Migration and Invasion by Downregulating CCDC134. (PMID:36056852)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.