MIR1261

Summary

MIR1261 (microRNA 1261, HGNC:35327) is a microRNA gene on chromosome 11q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302228 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35327
Approved symbol	MIR1261
Name	microRNA 1261
Location	11q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1261
Ensembl gene	ENSG00000221586
Ensembl biotype	miRNA
Entrez	100302228
RNAcentral	URS000075992E — miRNA, 82 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408659

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408659 — 1 exons

Exon	Start	End
ENSE00001565294	90869121	90869202

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 88.12.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	88.12	gold quality
blood	UBERON:0000178	86.20	gold quality
putamen	UBERON:0001874	74.19	gold quality
lymph node	UBERON:0000029	73.93	gold quality
endometrium	UBERON:0001295	72.92	gold quality
right atrium auricular region	UBERON:0006631	72.52	gold quality
calcaneal tendon	UBERON:0003701	72.19	gold quality
gastrocnemius	UBERON:0001388	71.36	gold quality
tibial artery	UBERON:0007610	70.34	gold quality
heart left ventricle	UBERON:0002084	70.00	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.52	gold quality
transverse colon	UBERON:0001157	65.41	gold quality
body of stomach	UBERON:0001161	65.11	gold quality
skin of abdomen	UBERON:0001416	65.02	gold quality
amygdala	UBERON:0001876	64.55	gold quality
omental fat pad	UBERON:0010414	64.39	gold quality
liver	UBERON:0002107	64.19	gold quality
esophagus mucosa	UBERON:0002469	63.64	gold quality
right lobe of liver	UBERON:0001114	62.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	62.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.16	gold quality
lower esophagus muscularis layer	UBERON:0035833	61.83	gold quality
skin of leg	UBERON:0001511	61.35	gold quality
body of uterus	UBERON:0009853	60.49	gold quality
tibial nerve	UBERON:0001323	60.03	gold quality
spleen	UBERON:0002106	59.92	gold quality
colon	UBERON:0001155	59.46	gold quality
left lobe of thyroid gland	UBERON:0001120	58.71	gold quality
stomach	UBERON:0000945	55.60	gold quality
left testis	UBERON:0004533	43.95	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Identified a new circRNA, circZFR, that was significantly upregulated in papillary thyroid carcinoma (PTC). CircZFR could promote C8orf4 expression via serving as a competing endogenous RNA of miR-1261 in PTC cells. Rescue assays indicated that restoration of C8orf4 significantly attenuated the inhibitory effects of circZFR knockdown on PTC cell proliferation, migration and invasion. (PMID:29842886)
• Expression of circ-PTPRZ1/PAK1 is regulated by miR-1261, which affects the proliferation, apoptosis, and invasion of glioma cells. (PMID:31364003)
• LncRNA BCAR4 promotes liver cancer progression by upregulating ANAPC11 expression through sponging miR1261. (PMID:32319544)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.