MIR1262

Summary

MIR1262 (microRNA 1262, HGNC:35328) is a microRNA gene on chromosome 1p31.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302279 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35328
Approved symbol	MIR1262
Name	microRNA 1262
Location	1p31.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1262
Ensembl gene	ENSG00000221203
Ensembl biotype	miRNA
Entrez	100302279
RNAcentral	URS000075B14C — miRNA, 93 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408276

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408276 — 1 exons

Exon	Start	End
ENSE00001564911	68183518	68183610

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 81.82.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	81.82	gold quality
endometrium	UBERON:0001295	80.30	gold quality
adrenal tissue	UBERON:0018303	79.92	gold quality
monocyte	CL:0000576	78.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.51	gold quality
calcaneal tendon	UBERON:0003701	78.13	gold quality
stomach	UBERON:0000945	77.55	gold quality
kidney	UBERON:0002113	75.15	gold quality
tibial artery	UBERON:0007610	75.14	gold quality
gastrocnemius	UBERON:0001388	75.08	gold quality
heart	UBERON:0000948	74.65	gold quality
liver	UBERON:0002107	74.52	gold quality
right adrenal gland	UBERON:0001233	73.45	gold quality
metanephros cortex	UBERON:0010533	73.42	gold quality
popliteal artery	UBERON:0002250	73.36	gold quality
islet of Langerhans	UBERON:0000006	72.73	gold quality
right adrenal gland cortex	UBERON:0035827	71.68	gold quality
body of stomach	UBERON:0001161	70.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.60	gold quality
lung	UBERON:0002048	70.56	gold quality
intestine	UBERON:0000160	70.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.80	gold quality
body of pancreas	UBERON:0001150	69.67	gold quality
ascending aorta	UBERON:0001496	69.51	gold quality
right coronary artery	UBERON:0001625	69.25	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.09	gold quality
lower esophagus	UBERON:0013473	69.06	gold quality
granulocyte	CL:0000094	68.70	gold quality
urinary bladder	UBERON:0001255	68.61	gold quality
esophagus	UBERON:0001043	68.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Our findings confirmed the important role that genetic variants of noncoding sequence play in lung cancer susceptibility and indicated that rs12740674 in miR-1262 may be biologically relevant to lung carcinogenesis. (PMID:28510306)
• LRP8, modulated by miR-1262, promotes tumour progression and forecasts the prognosis of patients in breast cancer. (PMID:31994910)
• Investigating aberrantly expressed microRNAs in peripheral blood mononuclear cells from patients with treatmentresistant schizophrenia using miRNA sequencing and integrated bioinformatics. (PMID:33000265)
• Exosomes derived from the blood of patients with sepsis regulate apoptosis and aerobic glycolysis in human myocardial cells via the hsamiR1262/SLC2A1 signaling pathway. (PMID:35137927)
• NF-kappaB downstream miR-1262 disturbs colon cancer cell malignant behaviors by targeting FGFR1. (PMID:37867436)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.