MIR1263

Summary

MIR1263 (microRNA 1263, HGNC:35329) is a microRNA gene on chromosome 3q26.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302148 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35329
Approved symbol	MIR1263
Name	microRNA 1263
Location	3q26.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1263
Ensembl gene	ENSG00000221251
Ensembl biotype	miRNA
Entrez	100302148
RNAcentral	URS000075A6CB — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408324

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408324 — 1 exons

Exon	Start	End
ENSE00001564959	164171471	164171556

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 80.81.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
intestine	UBERON:0000160	80.81	gold quality
blood	UBERON:0000178	79.31	gold quality
monocyte	CL:0000576	75.80	gold quality
metanephros cortex	UBERON:0010533	70.84	gold quality
adult mammalian kidney	UBERON:0000082	65.00	gold quality
right testis	UBERON:0004534	58.35	gold quality
testis	UBERON:0000473	48.73	gold quality
left testis	UBERON:0004533	44.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-1263 promotes endoderm differentiation. miR-1263 directly targets KLF4. (PMID:29141233)
• The expression of circulating hsa-miR-126-3p in dengue-infected Thai pediatric patients. (PMID:35708203)
• Extracellular vesiclemediated miR1263p transfer contributes to intercellular communication in the liver tumor microenvironment. (PMID:36660950)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.