MIR1264

Summary

MIR1264 (microRNA 1264, HGNC:35246) is a microRNA gene on chromosome Xq23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302251 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35246
Approved symbol	MIR1264
Name	microRNA 1264
Location	Xq23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1264
Ensembl gene	ENSG00000276158
Ensembl biotype	miRNA
Entrez	100302251
RNAcentral	URS000075A661 — miRNA, 69 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000616374

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000616374 — 1 exons

Exon	Start	End
ENSE00003734661	114652655	114652723

Expression profiles

Bgee: expression breadth broad, 14 present calls, max score 74.93.

Top tissues by expression

14 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	74.93	gold quality
monocyte	CL:0000576	74.03	gold quality
amygdala	UBERON:0001876	70.62	gold quality
heart left ventricle	UBERON:0002084	70.47	gold quality
ascending aorta	UBERON:0001496	69.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.09	gold quality
corpus callosum	UBERON:0002336	66.90	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.90	gold quality
putamen	UBERON:0001874	65.22	gold quality
thoracic mammary gland	UBERON:0005200	65.19	gold quality
nucleus accumbens	UBERON:0001882	63.57	gold quality
vagina	UBERON:0000996	63.29	gold quality
caudate nucleus	UBERON:0001873	62.77	gold quality
left testis	UBERON:0004533	47.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Epigenetic inhibition of SOCS3 is regulated by miR1264 which specifically targets DNMT1 transcript. (PMID:26047583)
• LncRNA SOCS2-AS1 inhibits progression and metastasis of colorectal cancer through stabilizing SOCS2 and sponging miR-1264. (PMID:32437330)
• circRNA0006896miR1264DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis. (PMID:33649864)
• Circular RNA Circ_0001322 inhibits gastric cancer progression by modulating the miR-1264/QKI axis and suppressing the Hedgehog pathway. (PMID:38814217)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.