MIR1265

Summary

MIR1265 (microRNA 1265, HGNC:35332) is a microRNA gene on chromosome 10p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100302116 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:35332
Approved symbol	MIR1265
Name	microRNA 1265
Location	10p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-1265
Ensembl gene	ENSG00000221371
Ensembl biotype	miRNA
Entrez	100302116
RNAcentral	URS00006A766D — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000408444

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000408444 — 1 exons

Exon	Start	End
ENSE00001565079	14436576	14436661

Expression profiles

Bgee: expression breadth broad, 25 present calls, max score 76.84.

Top tissues by expression

25 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.84	gold quality
endometrium	UBERON:0001295	74.89	gold quality
stomach	UBERON:0000945	74.52	gold quality
gastrocnemius	UBERON:0001388	73.86	gold quality
body of pancreas	UBERON:0001150	72.57	gold quality
body of stomach	UBERON:0001161	72.54	gold quality
heart left ventricle	UBERON:0002084	70.64	gold quality
right atrium auricular region	UBERON:0006631	69.41	gold quality
omental fat pad	UBERON:0010414	67.73	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.53	gold quality
gall bladder	UBERON:0002110	66.15	gold quality
right frontal lobe	UBERON:0002810	65.86	gold quality
rectum	UBERON:0001052	65.76	gold quality
cerebellar hemisphere	UBERON:0002245	64.58	gold quality
amygdala	UBERON:0001876	64.26	gold quality
caudate nucleus	UBERON:0001873	64.12	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.03	gold quality
vagina	UBERON:0000996	63.85	gold quality
skin of abdomen	UBERON:0001416	63.81	gold quality
right ovary	UBERON:0002118	63.29	gold quality
thyroid gland	UBERON:0002046	61.80	gold quality
transverse colon	UBERON:0001157	61.75	gold quality
spleen	UBERON:0002106	60.91	gold quality
tibial nerve	UBERON:0001323	58.47	gold quality
prostate gland	UBERON:0002367	55.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• miR-1265 suppresses gastric cancer progression and oncogenic autophagy by reducing CAB39 expression and regulating the AMPK-mTOR signaling pathway. (PMID:30779944)
• CircPICALM can inhibit BC metastasis and bind to miR-1265 to block its pro-invasion activity. (PMID:31648990)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.